We’ll try again and we’ll fail again because that’s what progress looks like. Progress looks like a bunch of failures. And you’re going to have feelings about that because it’s sad, but you cannot fall apart. And then one day, we will succeed and save a person’s life and we will walk on the moon.

Meredith

[narrating] "The early bird catches the worm; a stitch in time saves nine. He who hesitates is lost. We can't pretend we haven't been told. We've all heard the proverbs, heard the philosophers, heard our grandparents warning us about wasted time, heard the damn poets urging us to ‘seize the day'. Still sometimes we have to see for ourselves. We have to make our own mistakes. We have to learn our own lessons. We have to sweep today's possibility under tomorrow's rug until we can't anymore, until we finally understand for ourselves like Benjamin Franklin meant. That knowing is better than wondering, that waking is better than sleeping. And that even the biggest failure, even the worst most intractable mistake beats the hell out of never trying."

MEREDITH

Never make yourself small for anyone. Be your own person. And try wearing a little lipstick.

Diane

We spend our whole lives worrying about the future, planning for the future, trying to predict the future, as if figuring it out will cushion the blow. But the future is always changing. The future is the home of our deepest fears and wildest hopes. But one thing is certain when it finally reveals itself. The future is never the way we imagined it.

Meredith (closing voiceover)

[in flashback]
Meredith: I have no story. I'm just a girl in a bar.
Derek: I'm just a guy in a bar.

Shut up. Just shut up. You don't get to tell me that we're not together. We are together. Because I love you and you love me, and none of the rest of it matters. We are together. And if you ever sleep with anyone else again, man or woman, I will kick the crap out of you. Now you sit your ass back down there because that's my baby in there. I don't want anything happening to my baby.

Arizona

Izzie: They tried number 9? Who does 9?
Sadie: Well personally I'm a fan of 5, 7, 8, pretty much 12 through 20.
Meredith (laughs): I would try 15.
Izzie: Don't. Don't try 15. I would try 16. Yeah. I've never done that before.
Alex: You'd try 16?
Izzie: Uh huh. I would. I totally would. (Izzie and Alex look at each other then quickly leave the table)
Lexie: Um, don't do 16 too fast. It can hurt badly ... I heard.

I don't have to say a word. She just looks at me and sees who I am and how I feel and accepts it. She doesn't try to change it or wants to change it. That person. There's a billion people but I imagine there's only one of her.

Owen

Callie: Did anyone ever think you two were a couple?
Meredith: No, because we screw boys like whores on tequila.
Cristina: Then we either try to marry them or drown ourselves.
Callie: Huh.

[narrating] "Maybe we're not supposed to be happy. Maybe gratitude has nothing to do with joy. Maybe being grateful means recognizing what you have for what it is. Appreciating small victories. Admiring the struggle it takes simply to be human. Maybe we're thankful for the familiar things we know. And maybe we're thankful for the things we'll never know. At the end of the day, the fact that we have the courage to still be standing is reason enough to celebrate."

MEREDITH

Alex: What is this?
Izzie: Take off your pants.
Alex: Iz, it's a...
Izzie: Be my husband, get undressed, get into bed and hold me. I don't know what you're so mad about and I don't know what you're scared of because you won't talk to me. But, I'm scared too Alex. And I can't... if you won't... If we're gonna have any chance at a life together then I need you to. Please...
Alex: You died in my arms. You died in my arms! You freakin died, and then you left instructions that I wasn't allowed to save your life. You wanna know what I'm scared of? I'm scared of everything. I'm scared to move. I'm scared to breathe. I'm scared to touch you. I can't lose you. I won't survive. And that's your fault. You made me love you, you made me let you in. And then you freaking died in my arms.

You know, whenever anyone says something really funny and I laugh I always look around to see if you think it's funny too. Even when you are not there, I look around.

George

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.