Charlie, the truth is you were a bastard. You were, you were mean and stubborn and just a bastard. But you were a bastard who knew what you wanted and you stuck to your guns and you proved that if you want something badly enough, if you're determined enough and appreciative enough eventually it will happen. It will, that gives me hope so thanks for that. Good bye, Charlie.

Izzie

He didn't fart much.

Alex

George! It's really old guy! We could bring a marching band in here and he wouldn't know the difference!

Izzie

Blondieee!!

Charlie

George: Did you know how to do the procedure?
Richard: Are you saying that we're too old to learn the new ways, O'Malley?
George: No.
Richard: Are you saying we're old dogs who can't learn the tricks?
George: No. I just...
Mark: We're not old dogs.
Webber: We still got it.

Meredith: I will take the ER and your interns.
Cristina: Are you sure?
Meredith: Take the surgery. Makes you feel better and you start to regain strength. [leaves]
Alex: I saw the whole thing, Yang. You can stop pretending.
Cristina: Oh I'm not pretending. I'm sad. I'm very sad. Me so sad!
Alex: Yes, you tried.
Cristina: Hey, forget it. Sad is mine. Go, find your own pretend-emotion.

Meredith: Cristina, are we gonna talk about this? The Burke thing?
Cristina: I'm not Izzie. I'm not gonna lie on the bathroom floor all day. I'm gonna lie here. On the counter.

I'm stuck in the pit with this know-nothing interns. You'd think eventually I'd catch a break.

Cristina

Mark: Ever feel like you're gettin' old?
Derek: Meredith isn't telling Cristina about us. She tells Cristina everything.
Mark: I thought you broke that off!
Derek: I meant to.
Mark: You think she's gonna wanna get back together. You think she's gonna grow up, and get all whole, and want a relationship.
Derek: I do not.
Mark: [smiles] You're a bad liar.
Derek: [smiles] You're old.
Mark: I'm just getting started my friend.

Meredith: Hey.
Cristina: [pretending to be sad] Hey.
Meredith: You okay?
Cristina: I don't know. I think it's all just hiding me. Stupid Burke dumping me and then stupid Mama coming to reclaim her magic necklace.
Meredith: You wanna to talk about it?
Cristina: No, not really, not yet.
Meredith: Okay, well if there's anything I can do.
Cristina: I just wish I could do surgery, surgery would make me feel better...
Meredith: [looks critical]
Cristina: 1, 2, 3, 4, follow me!

She's doing McDreamy! She's doing McDreamy and lying about it. Did she thinks I'm weak, that I'm fragile?! Did she think I can't handle it because of Burke?

Cristina

Callie: Just say it.
George: I slept with Izzie.

Grey's Anatomy Season 4 Quotes

I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie

[narrating] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or ... we get left behind.

Meredith