Meredith: We agreed, S and M only.
Derek: S and M?
Meredith: Sex and mockery.

Meredith: Hey, what's the 911?
Cristina: Mama is here.
Meredith: Your mother?
Cristina: No, not my mother. Mama. MAMA is here.
Meredith: Oh, Burke's mother.
Cristina: Yeah, make the synapses fire a little more quickly, Meredith.

Chief: What do we have?
Callie: Gas main blew in an apartment building, five injured, some badly.
Cristina: Excellent.... Horrible, horrible! Sad.

Cristina: Follow!
Lexie: We're not gonna round?
Cristina: Carnage trumps rounds. Three. Write that down. Carnage always trumps rounds.

Carnage in the pit. My day is improving!

Cristina

Bailey: Would you look at the residents, big snazzy residents, standing around playing with housewares.
Christina: Turn a blind eye and the soup tureen's yours.

Derek: You're like the worst, most juvenile human being I've ever met in my life.
Mark: You know the first step to recovery is admitting you have a problem?
Derek: How many nurses have you slept with this week?
Mark: That's not a problem, man. That’s an adventure!

Mark: Let me guess, you and Grey are back together and you've been up all night doing the horizontal salsa.
Derek: Mambo. Horizontal mambo. Meredith and I, we're just friends.
Mark: Sexy friends.

[narrating] In the hospital, we see addiction every day. It's shocking how many kinds of addiction exist. It would be too easy if it were just drugs and booze and cigarettes. I think the hardest part of kicking a habit is wanting to kick it. I mean, we get addicted for a reason, right? Often, too often, things that start out as just a normal part of your life at some point cross the line to obsessive, compulsive, out of control. It's the high we're chasing, the high that makes everything else fade away.

Meredith

Alex: I'm going over Callie's head to Bailey.
Cristina: Callie is over Bailey's head...
Meredith: Spiritually, Bailey's over everyone's head.

Meredith's mother never wanted her and her father was never man enough to hang around. She has a right to be damaged. And us, together? It's a big step for her. Her best friend gets left at the altar, and all she sees now is, things like this, they don't work. She panics. She wants this, she doesn't know how to have it. And you know what? It's not her fault. So don't ever talk to me about Meredith Grey again because you do not know what you are talking about. And I don't want a friend.

Derek

Mark: I really am up for a drink, you know if you need to talk.
Derek: What would I need to talk about?
Mark: Meredith. You were lucky, man. That girl jerked you around.
Derek: You have no idea what you're talking about.

Grey's Anatomy Season 4 Quotes

I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie

[narrating] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or ... we get left behind.

Meredith