(to her interns) I know... I know you didn’t wake up this morning expecting this was how your first day was gonna go. You thought you’d get to re-attach an arm or observe brain surgery; instead you helped save the life of a deer. You can bitch and complain about it, or you can adjust your expectations. 'Cause like it or not, you are stuck with me and I’m the kind of doctor who lets little kids convince her she can do the impossible. Oh! Plus, when I woke up this morning, I thought today was gonna go a lot differently too. I thought I was gonna get the good interns. Instead, I get stuck with the duds! So I'll have to adjust my expectations as well.

Izzie

Meredith: Have you seen Burke?
Cristina: No. Have you seen Derek?
Meredith: No.
Izzie: Wait, you haven't seen either of them since the wedding?
Meredith and Cristina: Nope.
Izzie: And you're all fine?
Meredith: Yep.
Cristina: Yep.
Izzie: Wow. You're either incredible healthy or completely messed up.

George! Severed arm, Meredith's half sister is my intern, Izzie's playing Dr. Doolittle, oh, and Alex hates your wife.

Cristina

Derek: How is Meredith, anyway?
Cristina: Fine.
Derek: She's always fine. That's her problem.
Cristina: We're fine people. We do fine. We're fine.

Mark: I didn't come to Seattle for Addison, I didn't come to Seattle to be chief. I came to Seattle for you, okay? I came to Seattle to get you back... [laughs] I know I wanna take that back, but now, it's been said..
Derek: Yeah... maybe we should have a drink.
Mark: We could?
Derek: [smiles] Yeah.... Not today.

Don't you see? I'm Bambi. I'm Bambi, George. If anyone in this situation is a sad little cartoon character, it's me. I'm all alone in the forest, all alone in the forest, George. And my mother's been shot by a hunter and where are you? Where the hell are you?

Izzie

I don't respond to being called a number.

George

Derek: We're broken up.
Meredith: It's done.
[They start kissing]
Derek: Break-up kiss.
Meredith: Break-up kiss.
Derek: Lets have break-up sex.
Meredith: Yeah, lets have break-up sex.

Meredith: I...uhm....
Derek: You're not ready for this.
Meredith: No.
Derek: I asked for too much.
Meredith: I think so.
Derek: So, this is it?
Meredith: Yeah.
Derek: We're breaking up?
Meredith: We're breaking up.

Alex: Callie's a bitch.
Izzie: Word!

Meredith: [narrating] Change; we don’t like it, we fear it, but we can't stop it from coming. We either adapt to change or we get left behind. And it hurts to grow, anybody who tells you it doesn’t is lying. But heres the truth: the more things change, the more they stay the same. And sometimes, oh, sometimes change is good. Oh, sometimes, change is ... everything.

Cristina: I have five rules. Memorize them. Rule number one, don't bother sucking up. I already hate you, that's not gonna change.
Izzie: Traumas protocol, phone lists, pagers. The nurses will page you, you answer every page at a run. A RUN! That's rule number two... You're supposed to follow me!
Alex: The first shift starts now and lasts 36 hours. You're grunts, nobodies, the bottom of the surgical food chain. You run labs, write orders, work every second night until you drop. And you don't complain.
Meredith: On call rooms. Sleep when you can, where you can. You know, but not with anybody. Not attendings, especially not attendings. Sleeping with attendings, not a good idea. Where was I?
George: Er, rule number three. If you're sleeping, do not wake you unless the patient is actually dying.
Cristina: The dying patient better not be dead when I get there, because not only will you have killed someone, you will have woken me for no good reason. Are we clear? Yes?
Lexie: That was four rules. You said five.
Cristina: Rule number five. When I move, you move... Go!

Grey's Anatomy Season 4 Quotes

I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie

[narrating] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or ... we get left behind.

Meredith