Bobby: Did you know my first girl turned out to be a...
Dean: [hangs up] whoa, no.

You know what else? I get a pedicure once in a while.

Bobby

Tori Spelling. I'm a huge fan. Girl's a real talent.

Bobby

Dean: You know what I will have that other one [drink].
Bartender: I thought you were working?
Dean: I'm working up to it.

Castiel: It isn't the Horn of Truth.
Dean: What are you talking about? You were gone for like two seconds. Where did you look?
Castiel: Everywhere.

Dean: Are you kidding me? I have been on red alert about Sam and you come for some stupid horn?
Castiel: You asked me to be here and I came.
Dean: I've been asking you for days you d**k!

Bobby: There's a worse case scenario.
Dean: What? Saying he's my co-pilot? Yeah, I know.
Bobby: No, that'd be the other worst case.
Dean: Then what?
Bobby: Maybe it's just Sam.

These aren't vampires, man. These are douche bags.

Dean

I'm ok. I killed so many people on the way over here.

Dean

Dean: Newsflash Mr. Wizard: "vampires pee."

Dean: Are you wearing glitter?
Kid: I only do it to get laid, man.
Dean: Does it work?

You go with Efron. I've got Bieber.

Dean

Supernatural Season 6 Quotes

How do you keep your lawn so green? C'mon Dean, you've never been what I call, Brady.

Yellow-Eyed Demon

It's like chicks specifically dig unavailable guys.

Dean