Sheldon Cooper doesn't do cozy.

Sheldon

You know, I must say I go back and forth on this boyfriend-girlfriend thing, but those moments when you worship me really keep you in the running.

Sheldon

If you need my nose, you'll find it firmly lodged up the rectum of the tenure committee.

Kripke

If we really want science to advance, people should have chips implanted in their skulls that explode when they say something stupid.

Sheldon

Sheldon: Is there any reason you're keeping this dead goldfish?
Penny: Damn, I forgot to feed him and that I had him.
Sheldon: Well, now, did you also have a dog? Because I found what appears to be a battery-operated chew toy.
Penny: Party's over. Party's over.

If you'd let me pierce your brain with a hot needle in the right place you'd be happy all the time.

Amy

Bernadette's diary has some saucy bits.

Sheldon

Amy: Used me as a human shield?
Sheldon: I panicked. He looked taller than usual.

Sheldon, I swear to God I'm going to kill you.

Howard

Howard: It's ridiculous that we still have to walk up all these stairs.
Bernadette: Yeah, try doing it in heels.
Howard: I am.

My shirt is itchy and I wish I were dead.

Sheldon

I can't tell you that. I'm bound by closet organizer/organizee confidentiality.

Sheldon

The Big Bang Theory Season 6 Quotes

Amy: Soon my upper lip will be the same fake blonde as my beautiful best friend.
Penny: Hey, this is my natural hair color - Now.

Right now, Howard is staring down on our planet like a Jewish Greek god - "Zuesawitz".

Raj