In Miami, a small church burns to the ground but one mysterious artifact is spared. A painting that dates back to the 1500's with alien writing on the back.
Naturally, Coulson takes a personal interest in this painting and he goes into the field with May to retrieve it. This leads to some dancing and reminiscing about the good old days of field work.
Unfortunately, HYDRA is on the scene with Bakshi posing as General Talbot who crashes the party threatening to expose the two agents. A deal is struck to meet Talbot in an hour at his hotel to discuss the artifact.
Coulson sends May in first to do some reconnaissance, but she is captured and replaced by Agent 33 using a holographic mask. Bakshi then interrogates the real Agent May regarding the new S.H.I.E.L.D. and their location. The imposter regroups with Coulson.
At the bus, Agents 33 (as May) plants a high tech HYDRA device in the plane's computer system. The bus begins triggering one fail safe after another which will ultimately result in the destruction of the plane.
Fitz manages to works with the team by putting his insecurities aside. He helps save the plane and their lives. Fitz is finally bonding with his new teammates and is now on the road to recovery.
Agent 33 (as May) takes Coulson back to the hotel assuring him Talbot's intentions are real. He begins to suspect the imposter and tricks her into revealing herself.
Meanwhile, the real Agent May escapes and confronts her duplicate. The two fight it out and Coulson takes the painting from Bakshi. The dynamic duo escape before a team of HYDRA soldiers arrive.
Upon analyzing the painting, it's confirmed to be 500 years old but the mysterious writing is new. This means there's someone like Coulson out there somewhere carving the alien writing.
May's contingency plan for Coulson was generous and sweet but if he goes berserk she has to forget all that and kill him as ordered.
Elsewhere, Raina is threatened by Daniel Whitehall who gives her 48 hours to turn over the obelisk to HYDRA.