Kara learns that there's an alien with intel on Reign on Fort Rozz, but men can't go there and she won't have her powers. Imra offers to go with her, but they need more help. Kara asks Livewire and Psi to join the mission.
While on Fort Rozz, they lose communications with the DEO and discover they are hurdling towards a blue star and will burn up within hours. Imra and Psi stay behind to deal with that while Kara and Livewire try to find Jindah.
Reign learns of the mission and arrives just as Kara learns of two more Worldkillers. Reign kills Jindah before she can reveal anything else.
Winn re-establishes connection with Imra and Psi goes to help Kara and Livewire fight Reign. Livewire dies saving Kara's life, and Psi uses her power on Reign, which brings Sam out for a second. Reign regains control and escapes.
Alex is still stuck at home with a broken leg and offers to babysit for Ruby. She helps Ruby deal with a bully from school. Sam arrives to pick her up and admits to Alex that she doesn't know where she was and that's been losing time.
Kara tells Mon-El about the two Worldkillers, Purity and Pestilence, and says she needs to find them before Reign does. Cut to a woman who is hit by a car and survives, her eyes glowing.