From playing a doctor to portraying a patient...

Sarah Wayne Callies will guest star on an upcoming episode of House. Not much is known about the role, except that the actress will likely come down with a challenging case of some disease that will take almost an hour to diagnosis.

Callies starred on Prison Break as Dr. Sara Tancredi for most of that show's four-season run, except for a few episodes that saw the character supposedly die from a decapitation.

It's safe to assume her Patient of the Week on House won't suffer from that problem... but you never know.

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Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.