Caterina Scorsone to Guest Star on Grey's Anatomy

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As predicted, an all-Shepherd crossover is in the works at Shondaland.

Grey's Anatomy's Derek (Patrick Dempsey) and Private Practice's Amelia (Caterina Scorsone) will be repairing their relationship in the upcoming season of Grey's.

Caterina, who was just promoted to series regular on Private Practice, will appear in the third episode of Grey's this season, Shonda Rhimes confirmed to TV Guide.

The premise is simple: Amelia Shepherd goes to Seattle to reconcile with her brother, Derek. The two Shepherds have not been on speaking terms since Amelia turned to drugs while grieving the death of her father, who was shot and killed in front of her and Derek.

A Solemn Derek
Caterina Scorsone Pic

Derek and Amelia will reunite this fall.

"Family is family," Scorsone says. "Regardless of the strife and tension and drama between the family members, there's a connection that is so deep. Obviously Amelia has a lot of emotion surrounding Derek and that relationship and all the things they've been through together."

In an interesting twist, Amelia will be reluctant to head to Seattle to see her brother, though she'll get a supportive push from none other than Addison (Kate Walsh) to reconcile.

"There's a lot of unresolved emotions surrounding that whole relationship. Everyone can relate to that fear of confronting situations that may result in rejection," says Scorsone.

Grey's Anatomy and Private Practice both return Thursday, September 23. What are your thoughts on the Shepherds' relationship and the upcoming crossover? Discuss!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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she'll probably be surprised to see that derek has been shot as well.

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!!!!!!!
Seems like it'll be good. (8

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Wow someone other than Addison from PrP is coming to Grey's. That the real news.

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.