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19 Most Epic Grey's Anatomy Episodes: From the Pilot to the Present

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Grey's Anatomy has been a staple of our television lives for almost a decade at TV Fanatic.

Ever since its debut in the spring of 2005, Meredith Grey, Derek Shepherd and a strong cast of supporting players have occupied a special place in our hearts.

We've been through compelling cases galore, along with ups, downs, chills and thrills; shocking breakups, makeups and hookups; deaths, births and the occasional ghost visit.

Hey ... if you can bring Jeffrey Dean Morgan back, you gotta do it, by any means necessary.

Times change, cast members have come and gone, and things may not be what they once were, but even in its present form, Shonda Rhimes' creation still tugs at the heartstrings.

Here, we have picked out what we believe are the 19 most emotional, OMG-worthy and otherwise notable installments of the long-running ABC medical drama.

Scroll through and remember the most epic installments below:

19 Most Epic Grey's Anatomy Episodes
The series opens with Meredith removing a sofa pillow from the bare bottom of a man named Derek. The rest is history.
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A Hard Day's Night

1. A Hard Day's Night

The series opens with Meredith removing a sofa pillow from the bare bottom of a man named Derek. The rest is history.


2. Freedom

As the fourth season finale gets underway, Meredith Grey works with Dr. Wyatt to understand what her mother was trying to tell her. By the time it ends, she has found catharsis, and her partner in life.

Map of You

3. Map of You

This Derek-centric hour was one of the high points of Season 10 so far, proving that the show's still got it.

Beautiful Doom

4. Beautiful Doom

As much as we love the majority of the collective cast, there is just something electric when the story is centered on Meredith and Cristina, as this Season 9 installment proved.

Dark Was the Night

5. Dark Was the Night

Henry passed and Teddy doesn’t know. Mer and Alex are stuck in the rain with a newborn and some bodies in the street. Cristina realized who she performed surgery on... and the news came that Zola is not coming back. Shonda tugged at our heartstrings on this one.

Adrift and at Peace

6. Adrift and at Peace

This installment was heartbreaking, emotional, well-paced, dramatic and a perfect sendoff for (hopefully) better things to come.

Give Peace A Chance

7. Give Peace A Chance

We absolutely loved this Derek-centric episode from early in the sixth season. It was one of Patrick Dempsey's best performances and a moving story to boot.

Remember the Time

8. Remember the Time

As Mark's chapter closed, this episode flashed back to the time after the plane crash while the doctors waited to be rescued and once they returned home.


9. Flight

Devastation. The plane crash that took place in the eighth season finale claimed multiple lives and changed others forever.

White Wedding

10. White Wedding

With plenty of tension from the parents, Callie and Arizona quickly realized their special day wasn’t turning out as they envisioned. Luckily, it all worked out in the end ... for now.

Death and All His Friends

11. Death and All His Friends

The sixth season finale stunningly concluded with a madman shooting up the hospital. Nothing would ever be the same at Seattle Grace.


12. Goodbye

Days 20-40 after the shocking death of George O'Malley saw the staff find some measure of closure, as the winds of change began to blow through Seattle.

What a Difference a Day Makes

13. What a Difference a Day Makes

As Grey's Anatomy turns 100, Meredith and Derek prepare to walk down the aisle as Izzie's condition brings back familiar (handsome!) symptoms. That's when MerDer decide to give their wedding away to Alex and Izzie.

Didn't We Almost Have it All

14. Didn't We Almost Have it All

We had a bad feeling from the start in the third season finale, which ended with MerDer's split, Burke's shocking departure and Yang bawling on the floor.

Some Kind of Miracle

15. Some Kind of Miracle

As Part III of this three-episode story line commenced, we could only hope that a hypothermic Meredith is somehow brought back to life. Thanks to some help in the afterlife, she was.

It's the End of the World...

16. It's the End of the World...

We have… a code… black. These words echoed through our minds for two weeks in advance, as ABC hyped its post-Super Bowl episode of the soon to be Thursday night staple.

(As We Know It)

17. (As We Know It)

… The tension continues with Meredith keeping her hand on the bomb, Derek refusing to leave the O. R. , Dr. Bailey in labor and much, much more.

Who's Zoomin' Who?

18. Who's Zoomin' Who?

George makes an interesting discovery in the first season finale ... but it's nothing like the bomb that gets dropped on Meredith in the form of Addison.

Into You Like a Train

19. Into You Like a Train

From the second season, perhaps the show's best-ever episode with the tension gripping viewers from start to finish.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.


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    4 Comments New Comment Subscribe


    I couldn't agree more on "Into You like A train" being the best episode ever of Grey's Anatomy! Given there are so many to chose from, I would definitely have picked it!

    I would say Golden Hour was also a really good episode showing how Meredith changed as a person and a doctor through the years. Another one really close to my heart is The Becoming from season 4 with the song "Know When To Walk Away" playing.


    Golden Hour from season 7 was amazing.How did it not end up here?The scene with the emergency surgery with Teddy and Meredith-was epic.Most powerful scene I have ever seen in quite a while :)


    love the show.. since day one... alwys watch the reruns....
    too.... never get enough especially mer.der.... all time fav. couple..they fit so well toghtr..... hpefully will not leave the show..wouldntbe the same without them.....


    What about deterioration of the fight or flight response/losing my religion???
    The season 2 finale was AMAZING.
    Still goes down in the books as one of the best episodes of Grey's.

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