Dr. Lisa Cuddy is House's bosses. You can imagine how much fun that must be!

She's the Hospital Administrator and Dean of Medicine, meaning House must seek Cuddy's approval before peforming many of his crazy surgeries/theories. On a personal level, there's constant sexual tension between Cuddy and House.

He often remarks on the size of her breasts, while the pair made out about halfway through season four of the show.

Dr. Lisa Cuddy Quotes

Dr. Cuddy: You want to kiss me, don't you?
House: I always want to kiss you.

(to House) Oh, I looked into that philosopher you quoted. Jagger. And you're right. You can't always get what you want, but as it turns out, if you try sometimes, you get what you need.

Dr. Cuddy