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Dr. Lisa Cuddy is House's bosses. You can imagine how much fun that must be!
She's the Hospital Administrator and Dean of Medicine, meaning House must seek Cuddy's approval before peforming many of his crazy surgeries/theories. On a personal level, there's constant sexual tension between Cuddy and House.
He often remarks on the size of her breasts, while the pair made out about halfway through season four of the show.