When someone falls to the floor, Derek and Owen fight to save a life in "Do You Know?"

Whatever's going on, Derek looks very serious on Grey's Anatomy.

It's like Derek is smiling into our soul in this Grey's Anatomy image, isn't it?

It's Derek vs. Meredith! These two did not end Grey's Anatomy Season 10 on a positive note.

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

Everyone wants Derek, even the President of the United States is giving him a call on Grey's Anatomy.

Unfortunately for McDreamy, Meredith may be the one person who isn't awed by his big news in "Take It Back"

This is a nice Meredith and Derek moment, isn't it? Some Grey's Anatomy fans say we don't see enough of these anymore.

Derek and Amelia are having some issues on Grey's Anatomy. They are not getting along professionally in any way, shape or form.

Derek looks on in this scene from Grey's Anatomy Season 11. It's from the episode "Can We Start Again Please?"

Oh, Derek Shepherd, how we miss you already. This is a photo from McDreamy from his final episode.

NOOOOO!!! Grey's Anatomy has gone there. It has killed off Derek Shepherd.