It looks like that's about to happen in the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," which we see a scene from here.
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At least Izzie seems to be. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Stevens and other doctors at Seattle Grace stand outside. What will happen next?!
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," five of our favorite Seattle Grace staff members stand outside. Something tells us something bad is going to happen.
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," four of our favorite Seattle Grace staff members stand outside their place of employment.
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Izzie helps a trauma patient out of the car. Looks intense!
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Don't count on it, according to some of the Grey's Anatomy spoilers we've read.
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Izzie is up in the face of Alex, ready to tell him how she feels. How will this end?
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Izzie is not about to take any more crap from Alex. This Rebecca stuff has gone on long enough.
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Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

Callie: Did anyone ever think you two were a couple?
Meredith: No, because we screw boys like whores on tequila.
Cristina: Then we either try to marry them or drown ourselves.
Callie: Huh.