It looks like that's about to happen in the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," which we see a scene from here.
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At least Izzie seems to be. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Stevens and other doctors at Seattle Grace stand outside. What will happen next?!
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," five of our favorite Seattle Grace staff members stand outside. Something tells us something bad is going to happen.
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," four of our favorite Seattle Grace staff members stand outside their place of employment.
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Izzie helps a trauma patient out of the car. Looks intense!
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Don't count on it, according to some of the Grey's Anatomy spoilers we've read.
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Izzie is up in the face of Alex, ready to tell him how she feels. How will this end?
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Izzie is not about to take any more crap from Alex. This Rebecca stuff has gone on long enough.
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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)