Izzie, Alex and Cristina at George's funeral. We will see this unfold when the new season of Grey's Anatomy airs.
Alex reacts as Izzie slips away from him, possibly for the last time.
Is Izzie about to slip away into the afterlife?
Alex calls for help as Izzie fades into unconsciousness.
Cristina and Izzie share a moment in "Now or Never."
Izzie Stevens crashes at the end of "Now or Never." Will she live?
Alex and Izzie don't know what the best course of action is going forward, and it's hard to blame them.
Izzie and Alex embrace in the fifth season finale.
Izzie Stevens may be bald, but she's still hot in the eyes of Alex Karev, and all of us.
Meredith tries to help Izzie remember images while Derek runs tests.
Has Izzie Stevens passed away? If that is what we are supposed to take away from the powerful scene at the end, it was certainly emotionally devastating, but great television.
Alex tends to ailing Izzie in an emotional Season Five scene from Grey's Anatomy. These two have become bigger and bigger characters since the series debuted.

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.