Alex and Izzie embrace after getting married in "What a Difference a Day Makes," the 100th episode of Grey's Anatomy, from Season Five. It was a great Grey's moment, no question about it.
George and Izzie will always be close, even though their relationship has been through its ups and downs. What a wonderfully-written scene this was, when he helped her down the aisle.
The big wedding finally took place - and it wasn't the people who were scheduled to get married on this date and in that venue. But it was still magical.