Supernatural Siblings

Sam and Dean are the two main reasons why Supernatural is such a hit. These two are great together.
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Armed

Spotted in this scene: Samantha Ferris as Ellen, Jensen Ackles as Dean, Jared Padalecki as Sam, Alona Tal as Jo Beth.
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Jared Padalecki as Sam

Nothing too fancy about this shot of Jared Padalecki as Sam. It's a scene from "Abandon All Hope."
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From The Real Ghostbusters

Sam and Dean attend a fan convention on the episode "The Real Ghostbusters. An adventure ensues.
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Supernatural Studs

Seen here, in this scene from The Real Ghostbusters: Jensen Ackles as Dean and Jared Padalecki as Sam.
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Fan Convention

Sam is seen here at a Supernatual fan convention. The scene is from the episode "The Real Ghostbusters."
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Changing Channels Scene

This is a scene from "Changing Channels." During this episode, Sam and Dean are trapped inside various TV shows.
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As Doctors

Sam and Dean as doctors? We don't want them operating on us!
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Pleasure to Meet You

Sam shakes the hand of a special kid during this scene from Supernatural. He can make fairy tales into reality.
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Supernatural Scene

Dean and Sam disagree over a child that can turn fairy tales into reality. This is a shot from "I Believe the Children Are Our Future."
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Sam and Dean Photo

Sam and Dean run into their worst enemy yet on the episode "Fallen Idol." Paris Hilton guest stars!
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Listen Up, Sam

When Lucifer talks, it's hard not to listen. He has a message for Sam here.
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Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean