Kind of makes you nostalgic for good old fashioned herpes.

Dean

Woman: What kind of FBI agents are you?!
Dean: The fake kind.

What's a dad bod?

Dean

As long as everyone wears a condom we'll be fine.

Jody

What’s done is done. All that matters now, all that’s ever mattered, is that we’re together. So shut up, and drink your beer.

Dean

Dean: I always did have a thing for Blanche on Golden Girls.
Sam: Seriously?
Dean: Hey, don’t judge what you don’t understand, Sammy.
Sam: No, I’m not judging. I just always had a thing for Sophia.
Dean: Yeah, I can see that.

I’m here to save you all. Lucifer ex machina.

Lucifer

Sam: Turns out Harold was stealing the other residents' Viagra.
Dean: I know. It's a real dick move.

Dean: Your hand is still on my knee.
Mildred: I could move it up.

Snapping necks and cashing checks, it's what i do.

Lucifer

Dean: Where's Sam?
Crowley: Don't worry about Sam.
Dean: Oh I'm sorry, have you met me?

Get the hell out of hell.

Crowley

Supernatural Quotes

You betrayed me? No one in the history of torture's been tortured with torture like the torture you'll be tortured with.

Crowley

Just because you're blood doesn't mean you're family. You have to earn it.

Dean