Lois has a mid-life crisis triggered by her latest birthday on Family Guy. "Lois Comes Out of Her Shell" is the sixth episode of the show's 11th season.
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Family Guy Season 11 Episode 6 Quotes

Brian: And somebody replaced Meg's sleeping pills with Alka-Seltzer.
Meg: People are going to miss me when I [long burp].

Chris: Dad, how did you get Mom out of the house so we could decorate?
Peter: Well Chris, I constructed a very elaborate fake grocery store.