As Alex Karev waits, Izzie Stevens walks down the aisle to him, beaming and looking positively radiant despite her ailing condition.
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Izzie stumbled on her way down the aisle, but George stepped in and helped his old friend make it to the steps, where she exchanged vows with Alex. Tear.
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It was a sweet scene when George gave away Izzie to Alex at the wedding, when she became weak and could not walk under her own power. Tears were shed at this website.
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Alex and Izzie get married in "What a Difference a Day Makes," from the fifth season of Grey's Anatomy. What an emotional, 100th episode this was.
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Yup, you read that correctly. After yielding her own nuptials, Meredith Grey got the call to be the best man in Alex and Izzie's wedding.
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Lexie Grey (Chyler Leigh) in "What a Difference a Day Makes," from the fifth season of Grey's Anatomy. She and everyone else saw Izzie walk down the aisle with Alex.
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Mark Sloan (Eric Dane) is one of many hot and emotionally challenged doctors at Seattle Grace. But he's come a long way since dating Lexie.
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Mark and Lexie smile and cheer at the wedding of Alex and Izzie. These two have become a hot couple here in Season Five!
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Grey's Anatomy Season 5 Episode 22 Quotes

Minister: Dearly beloved. We are gathered here today to celebrate the wedding of Alexander Michael Karev and Isobel Katherine Stevens. This is a sacred right. An ancient right. As Isobel and Alex prepare to join their lives, it is important to understand that everyone present has played a part in shaping their lives. And, will continue to play a vital role in their continuing future. And thus, we are here not only to witness their vows to each other, but to bestow upon them our blessing. And, now the couple will read their vows.
Izzie: Oh, we didn't write anything.
Alex: No, wait. I have something I wanna say. Today's the day my life begins. All my life I've been just me. Just a smart mouth kid. Today I become a man. Today I become a husband. Today I become accountable to someone other than myself. Today I become accountable to you. To our future. To all the possibilities that a marriage has to offer. Together, no matter what happens, I'll be ready. For anything. For everything. To take on life, to take on love. To take on possibility and responsibility. Today Izzie Stevens, our life together begins. And I for one can't wait.
Izzie: I love you. (kisses him)
Minister: Ahem, not yet!
Alex: Hurry up!
Minister: By the power vested in me, by god and the state of Washington, I now pronounce you husband and wife.
Izzie: Now?
Minister: Now.
(Izzie and Alex kiss)

Cristina: You slept here?
Callie: I'm awake. What?
Cristina: You slept here? I slept here!
Callie: Um, how? Wait... who? What?
Cristina: I slept in the on call room.
Callie: Oh.
Cristina: I could have been at home in my own bed.
Callie: Sorry.
Cristina: Now I have to work all day, and then I have to be happy maid of honour and get Meredith down the aisle. I'm so tired, 'cause I slept here! 'Cause you wanted to get your freak on with roller skate girl.
Callie: I am sorry. I was gonna, but, we went to dinner and, things didn't... I wasn't in the mood. I had to be here early anyway, to run the ER, so...
Cristina: Oh, you're picking up extra shifts in the ER? So is ah, is Owen not here today?
Callie: Ah, he's here. Oh crap! I'm late. Hey.
Meredith: Hey.
Cristina: BIG DAY! Biggest day of your life!
Meredith: Don't do that! Don't do the peppy maid of honour thing, it's creepy!
Cristina: Really? Good. Wait... is this like the calm before the storm? Do you need me to drug you? Or shave of your eyebrows to numb you into submission?
Meredith: No! I'm fine. It's not the biggest day of my life. It's the biggest day of Izzie's life. I'm excited about the marriage, not some wedding. Anyway, she's the one that's gone all bridezilla.
Cristina: Briiiideeezillaaaaaaaaa...