As Alex Karev waits, Izzie Stevens walks down the aisle to him, beaming and looking positively radiant despite her ailing condition.
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Izzie stumbled on her way down the aisle, but George stepped in and helped his old friend make it to the steps, where she exchanged vows with Alex. Tear.
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It was a sweet scene when George gave away Izzie to Alex at the wedding, when she became weak and could not walk under her own power. Tears were shed at this website.
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Alex and Izzie get married in "What a Difference a Day Makes," from the fifth season of Grey's Anatomy. What an emotional, 100th episode this was.
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Yup, you read that correctly. After yielding her own nuptials, Meredith Grey got the call to be the best man in Alex and Izzie's wedding.
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Lexie Grey (Chyler Leigh) in "What a Difference a Day Makes," from the fifth season of Grey's Anatomy. She and everyone else saw Izzie walk down the aisle with Alex.
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Mark Sloan (Eric Dane) is one of many hot and emotionally challenged doctors at Seattle Grace. But he's come a long way since dating Lexie.
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Mark and Lexie smile and cheer at the wedding of Alex and Izzie. These two have become a hot couple here in Season Five!
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Grey's Anatomy Season 5 Episode 22 Quotes

Cristina: You slept here?
Callie: I'm awake. What?
Cristina: You slept here? I slept here!
Callie: Um, how? Wait... who? What?
Cristina: I slept in the on call room.
Callie: Oh.
Cristina: I could have been at home in my own bed.
Callie: Sorry.
Cristina: Now I have to work all day, and then I have to be happy maid of honour and get Meredith down the aisle. I'm so tired, 'cause I slept here! 'Cause you wanted to get your freak on with roller skate girl.
Callie: I am sorry. I was gonna, but, we went to dinner and, things didn't... I wasn't in the mood. I had to be here early anyway, to run the ER, so...
Cristina: Oh, you're picking up extra shifts in the ER? So is ah, is Owen not here today?
Callie: Ah, he's here. Oh crap! I'm late. Hey.
Meredith: Hey.
Cristina: BIG DAY! Biggest day of your life!
Meredith: Don't do that! Don't do the peppy maid of honour thing, it's creepy!
Cristina: Really? Good. Wait... is this like the calm before the storm? Do you need me to drug you? Or shave of your eyebrows to numb you into submission?
Meredith: No! I'm fine. It's not the biggest day of my life. It's the biggest day of Izzie's life. I'm excited about the marriage, not some wedding. Anyway, she's the one that's gone all bridezilla.
Cristina: Briiiideeezillaaaaaaaaa...

Meredith: Just a normal day.
Derek: Normal day. Going to work.
Meredith: Just a normal day, that ends in a ceremony in a churchy church.
Derek: This has nothing to do with us, we're just the bride and groom.
Meredith: We're getting married tonight.
Derek: We're getting married tonight (smiles)
Meredith: (smiles back)