Alex and Izzie embrace after getting married in "What a Difference a Day Makes," the 100th episode of Grey's Anatomy, from Season Five. It was a great Grey's moment, no question about it.
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Alex and Izzie tie the knot on a very special Grey's Anatomy. They're all special, but this was one for the ages.
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Alex sweeps Izzie off his feet by reciting the wedding vows he made up after being inspired by a patient's planned valedictory speech. Truly touching.
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Alex wows Izzie with heartfelt wedding vows.
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Cristina and Meredith talk to Izzie before her wedding to Alex. This episode, the 100th, was one of Grey's Anatomy's best in recent memory.
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Izzie Stevens' dream wedding is about to come true ... with her as the bride!
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Izzie and Alex tie the knot. Soon after, she was forced to shave her head as her body continues to battle cancer. Can she survive?
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Izzie Stevens got to attend her dream wedding, all right ... and in an even better way than she ever imagined. As the bride!
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Grey's Anatomy Season 5 Episode 22 Quotes

Cristina: You slept here?
Callie: I'm awake. What?
Cristina: You slept here? I slept here!
Callie: Um, how? Wait... who? What?
Cristina: I slept in the on call room.
Callie: Oh.
Cristina: I could have been at home in my own bed.
Callie: Sorry.
Cristina: Now I have to work all day, and then I have to be happy maid of honour and get Meredith down the aisle. I'm so tired, 'cause I slept here! 'Cause you wanted to get your freak on with roller skate girl.
Callie: I am sorry. I was gonna, but, we went to dinner and, things didn't... I wasn't in the mood. I had to be here early anyway, to run the ER, so...
Cristina: Oh, you're picking up extra shifts in the ER? So is ah, is Owen not here today?
Callie: Ah, he's here. Oh crap! I'm late. Hey.
Meredith: Hey.
Cristina: BIG DAY! Biggest day of your life!
Meredith: Don't do that! Don't do the peppy maid of honour thing, it's creepy!
Cristina: Really? Good. Wait... is this like the calm before the storm? Do you need me to drug you? Or shave of your eyebrows to numb you into submission?
Meredith: No! I'm fine. It's not the biggest day of my life. It's the biggest day of Izzie's life. I'm excited about the marriage, not some wedding. Anyway, she's the one that's gone all bridezilla.
Cristina: Briiiideeezillaaaaaaaaa...

Meredith: Just a normal day.
Derek: Normal day. Going to work.
Meredith: Just a normal day, that ends in a ceremony in a churchy church.
Derek: This has nothing to do with us, we're just the bride and groom.
Meredith: We're getting married tonight.
Derek: We're getting married tonight (smiles)
Meredith: (smiles back)