Alex and Izzie embrace after getting married in "What a Difference a Day Makes," the 100th episode of Grey's Anatomy, from Season Five. It was a great Grey's moment, no question about it.
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Alex and Izzie tie the knot on a very special Grey's Anatomy. They're all special, but this was one for the ages.
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Alex sweeps Izzie off his feet by reciting the wedding vows he made up after being inspired by a patient's planned valedictory speech. Truly touching.
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Alex wows Izzie with heartfelt wedding vows.
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Cristina and Meredith talk to Izzie before her wedding to Alex. This episode, the 100th, was one of Grey's Anatomy's best in recent memory.
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Izzie Stevens' dream wedding is about to come true ... with her as the bride!
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Izzie and Alex tie the knot. Soon after, she was forced to shave her head as her body continues to battle cancer. Can she survive?
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Izzie Stevens got to attend her dream wedding, all right ... and in an even better way than she ever imagined. As the bride!
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Grey's Anatomy Season 5 Episode 22 Quotes

Izzie: You never know the biggest day of your life is the biggest day. Not until it's happening. You don't recognize the biggest day of your life, not until you're right in the middle of it. The day you commit to something or someone. The day you get your heart broken. The day you meet your soul mate. The day you realize there's not enough time, because you wanna live forever. Those are the biggest days. The perfect days. You know?
Denny: I bet you ... you made a beautiful bride.
Izzie: It was a beautiful day.
Alex: You put the scarf on. I told you, you don't need it. You look gorgeous without it.
Denny: He's right.
Izzie: Go away now. Go away, I wanna be alone with my husband.
Alex: (Takes off her scarf, and kisses her forehead) My wife is hot!
(Izzie giggles and smiles)

Minister: Dearly beloved. We are gathered here today to celebrate the wedding of Alexander Michael Karev and Isobel Katherine Stevens. This is a sacred right. An ancient right. As Isobel and Alex prepare to join their lives, it is important to understand that everyone present has played a part in shaping their lives. And, will continue to play a vital role in their continuing future. And thus, we are here not only to witness their vows to each other, but to bestow upon them our blessing. And, now the couple will read their vows.
Izzie: Oh, we didn't write anything.
Alex: No, wait. I have something I wanna say. Today's the day my life begins. All my life I've been just me. Just a smart mouth kid. Today I become a man. Today I become a husband. Today I become accountable to someone other than myself. Today I become accountable to you. To our future. To all the possibilities that a marriage has to offer. Together, no matter what happens, I'll be ready. For anything. For everything. To take on life, to take on love. To take on possibility and responsibility. Today Izzie Stevens, our life together begins. And I for one can't wait.
Izzie: I love you. (kisses him)
Minister: Ahem, not yet!
Alex: Hurry up!
Minister: By the power vested in me, by god and the state of Washington, I now pronounce you husband and wife.
Izzie: Now?
Minister: Now.
(Izzie and Alex kiss)