George and Owen at the wedding of Alex and Izzie. These two make a great trauma surgeon team, as we've seen in recent weeks.
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Callie and Arizona certainly qualify as that. Whether you believe they are really lesbians or not, the acting by Jessica Capshaw and Sara Ramirez is terrific.
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Calliope Torres has been disowned by her family, but she loves Arizona, and she loves her work. We think this talented doctor will be okay.
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Arizona and Callie are one of Grey's Anatomy's newest and most controversial couples. They're doing better lately, although there is always a crisis around the corner.
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Callie and Arizona (Calzona) at the wedding of Alex and Izzie. Having gotten over their nonsensical fight over Callie's money problems, the two are back on good terms.
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Callie and Arizona share a kiss in the church where the wedding took place. The people getting married where not who we thought, but the magic of the day was still palpable.
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Derek didn't get married to Meredith in the 100th episode of Grey's Anatomy, but it was still pretty close to perfect.
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Alex Karev in "What a Difference a Day Makes" from the fifth season of Grey's Anatomy. What a difference he's made in the life of Izzie.
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Grey's Anatomy Season 5 Episode 22 Quotes

Cristina: You slept here?
Callie: I'm awake. What?
Cristina: You slept here? I slept here!
Callie: Um, how? Wait... who? What?
Cristina: I slept in the on call room.
Callie: Oh.
Cristina: I could have been at home in my own bed.
Callie: Sorry.
Cristina: Now I have to work all day, and then I have to be happy maid of honour and get Meredith down the aisle. I'm so tired, 'cause I slept here! 'Cause you wanted to get your freak on with roller skate girl.
Callie: I am sorry. I was gonna, but, we went to dinner and, things didn't... I wasn't in the mood. I had to be here early anyway, to run the ER, so...
Cristina: Oh, you're picking up extra shifts in the ER? So is ah, is Owen not here today?
Callie: Ah, he's here. Oh crap! I'm late. Hey.
Meredith: Hey.
Cristina: BIG DAY! Biggest day of your life!
Meredith: Don't do that! Don't do the peppy maid of honour thing, it's creepy!
Cristina: Really? Good. Wait... is this like the calm before the storm? Do you need me to drug you? Or shave of your eyebrows to numb you into submission?
Meredith: No! I'm fine. It's not the biggest day of my life. It's the biggest day of Izzie's life. I'm excited about the marriage, not some wedding. Anyway, she's the one that's gone all bridezilla.
Cristina: Briiiideeezillaaaaaaaaa...

Meredith: Just a normal day.
Derek: Normal day. Going to work.
Meredith: Just a normal day, that ends in a ceremony in a churchy church.
Derek: This has nothing to do with us, we're just the bride and groom.
Meredith: We're getting married tonight.
Derek: We're getting married tonight (smiles)
Meredith: (smiles back)