George and Owen at the wedding of Alex and Izzie. These two make a great trauma surgeon team, as we've seen in recent weeks.
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Callie and Arizona certainly qualify as that. Whether you believe they are really lesbians or not, the acting by Jessica Capshaw and Sara Ramirez is terrific.
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Calliope Torres has been disowned by her family, but she loves Arizona, and she loves her work. We think this talented doctor will be okay.
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Arizona and Callie are one of Grey's Anatomy's newest and most controversial couples. They're doing better lately, although there is always a crisis around the corner.
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Callie and Arizona (Calzona) at the wedding of Alex and Izzie. Having gotten over their nonsensical fight over Callie's money problems, the two are back on good terms.
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Callie and Arizona share a kiss in the church where the wedding took place. The people getting married where not who we thought, but the magic of the day was still palpable.
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Derek didn't get married to Meredith in the 100th episode of Grey's Anatomy, but it was still pretty close to perfect.
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Alex Karev in "What a Difference a Day Makes" from the fifth season of Grey's Anatomy. What a difference he's made in the life of Izzie.
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Grey's Anatomy Season 5 Episode 22 Quotes

Minister: Dearly beloved. We are gathered here today to celebrate the wedding of Alexander Michael Karev and Isobel Katherine Stevens. This is a sacred right. An ancient right. As Isobel and Alex prepare to join their lives, it is important to understand that everyone present has played a part in shaping their lives. And, will continue to play a vital role in their continuing future. And thus, we are here not only to witness their vows to each other, but to bestow upon them our blessing. And, now the couple will read their vows.
Izzie: Oh, we didn't write anything.
Alex: No, wait. I have something I wanna say. Today's the day my life begins. All my life I've been just me. Just a smart mouth kid. Today I become a man. Today I become a husband. Today I become accountable to someone other than myself. Today I become accountable to you. To our future. To all the possibilities that a marriage has to offer. Together, no matter what happens, I'll be ready. For anything. For everything. To take on life, to take on love. To take on possibility and responsibility. Today Izzie Stevens, our life together begins. And I for one can't wait.
Izzie: I love you. (kisses him)
Minister: Ahem, not yet!
Alex: Hurry up!
Minister: By the power vested in me, by god and the state of Washington, I now pronounce you husband and wife.
Izzie: Now?
Minister: Now.
(Izzie and Alex kiss)

Izzie: You never know the biggest day of your life is the biggest day. Not until it's happening. You don't recognize the biggest day of your life, not until you're right in the middle of it. The day you commit to something or someone. The day you get your heart broken. The day you meet your soul mate. The day you realize there's not enough time, because you wanna live forever. Those are the biggest days. The perfect days. You know?
Denny: I bet you ... you made a beautiful bride.
Izzie: It was a beautiful day.
Alex: You put the scarf on. I told you, you don't need it. You look gorgeous without it.
Denny: He's right.
Izzie: Go away now. Go away, I wanna be alone with my husband.
Alex: (Takes off her scarf, and kisses her forehead) My wife is hot!
(Izzie giggles and smiles)