In this scene from "The Becoming," Meredith and Derek prepare for a serious operation in their clinical trial. Will they be able to repair their own lives?

Meredith and Derek operate on the fake brain in preparation for their surgery.

Preston Burke is back! Sort of. The doctor who left Seattle Grace has apparently won a prestigious award. How will Cristina Yang react?

Can you argue with that? Patrick Dempsey is the sexiest TV star - and perhaps the sexiest star period - that we've ever seen.

Ellen Pompeo rocks. There is little else to say at this point.

Drs. Callie Torres and Erica Hahn kiss passionately on the fourth season finale of Grey's Anatomy, entitled "Freedom." What a scene!

In this photo from "Losing My Mind," Derek Shepherd (Patrick Dempsey) talks to a patient. We just hope he talks to Meredith Grey a lot, as well!

In this photo from "Losing My Mind," Derek Shepherd (Patrick Dempsey) and Meredith Grey (Ellen Pompeo) talk to their patients at Seattle Grace. They are dealing with their own personal issues, as well - we'll see how that goes.

In this photo from "Losing My Mind," Meredith Grey (Ellen Pompeo) continues to slowly confront her demons. When will she realize she can't let Derek Christopher Shepherd get away!?

In this photo from "Losing My Mind, Meredith Grey (Ellen Pompeo) wears an expression of concern as she tends to her patients. She is dealing with her own personal issues, as well. We all know that!

In this photo from "Losing My Mind," Derek Shepherd (Patrick Dempsey) and Meredith Grey (Ellen Pompeo) wear expressions of concern as they tend to their patients. They are dealing with their own personal issues, as well.

In this photo from "Losing My Mind," Derek and Meredith's patient shares a lighter moment.