You're looking at a photo from "The Pulled Groin Extrapolation." Sheldon and Leonard have a lot to discuss.
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The Big Bang Theory Season 5 Episode 3 Quotes

Bernadette: I'm not going to live with your mother. Not now. Not ever.
Howard: Somebody, obviously, has some mommy issues.

I've seen pictures of your mother. Keep eating.

Sheldon [to Penny]