Jason Gann stars in Wilfred as the show's title character. He's part man, part dog.
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Ryan chats it up with Wilfred in this scene from the series premiere. Yes, he's the dog next door.
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Wilfred Season 1 Episode 1 Quotes

Ryan: Get off.
Wilfred: I'm trying to!

Ryan: I thought it would make me sound Effete.
Wilfred: So does saying the word "effete."