Jason Gann stars in Wilfred as the show's title character. He's part man, part dog.
Ryan chats it up with Wilfred in this scene from the series premiere. Yes, he's the dog next door.

Wilfred Season 1 Episode 1 Quotes

Ryan: Get off.
Wilfred: I'm trying to!

Ryan: I thought it would make me sound Effete.
Wilfred: So does saying the word "effete."