Blair: (sees Chuck, smoking) Oh, don't stop on my account.
Chuck: Oh I had to, second hand smoke is bad for the uh...
Blair: I'm not pregnant. So goodbye mistake, so far in my past I can hardly remember it.
Chuck: You cannot be serious.
Blair: You can't be touching me. Look, if you were going to tell Nate, you would have done so in Monaco but you don't want him to hate you. Game over.
Chuck: Game's not over until I say it is.
Blair: Then go play with yourself.

Nate: Did you sleep with her? Huh!?
Chuck: She needed someone and I was there!

Lily: (to Serena) Don't leave your dirty package on the table.
Chuck: If I had a nickel for every time I heard that.
Bart: That's enough Chuck.

Serena: What is your problem?!?
Chuck: Specify the context.

Serena: What are you doing?
Eric: I'm hiding from my valet. He wanted to put my socks on for me this morning. Your servants are very attentive.
Chuck: You should meet Bergita the maid.
Serena: No! No he should not meet Bergita, he's 14. Ignore this person.
Chuck: May I remind you, Serena, that you used to have a sense of humor.

Serena: Okay let's get one thing straight. Our parents might be insisting on blending our households but I am not your sister. I do not share any of your DNA, nor do I ever wish to.
Chuck: Then I suggest you get new hand towels.

[on the phone] Serena didn't come home last night.

Serena: Dan puts me on a pedestal, if he knew the truth he will never look at me again.
Chuck: Your starting to scare even me. What did you do?
Nate: Cmon, you can tell us.
Blair: We've seen you with vomit in your hair, making out with investment bankers in the men's room at PJ Clark's. You don't have to hide anything from us.

Nate: She's right Serena, I mean none of us are saints.
Blair: [points at Chuck] Yeah, I had sex with him in the back of a limo.
Chuck: Several times.
Nate: I had sex with you, at a wedding while I was her date. [looks at Chuck] Once.
Blair: [looks at Chuck]
Chuck: I'm Chuck Bass!

Nate: What about her?
Serena: Well, something happened the night of the Shepherd's wedding.
Blair: I think we're all aware of what happened that night.
Serena: No, something else. Something I've tried to escape but Georgina won't let me. And now she's blackmailing me.
Nate: Blackmailing you?
Chuck: With what exactly?
Serena: Well, it started when Blair thought you and I had too much to drink. She told us to get some air, go outside, sober up.

Serena: Instead, we ended up in the bar and I opened that bottle of champagne and we... well...
Blair: We can skip that part, k?
Chuck: Go ahead, I'll fill her in later.
Serena: I left in a hurry. I felt so terrible, so guilty for what I'd just done. I just.. I had to get out of there. Georgina and I had plans to meet up after, so I headed straight to her... little did I know, she had a surprise waiting for me.

Chuck: Serena look effin hot last night. There's something wrong with that level of perfection. It needs to be violated.
Nate: You are deeply disturbed.

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.