Even Blair Waldorf can not bend DNA to her will.

Rufus: I dated a girl like Serena, once. Actually a lot like Serena. And girls like that might be challenging. That's true. And they're complicated, and enigmatic. And usually worth it. And the only way you know for sure is to jump it with both feet.
Dan: What happened with you?
Rufus: I swam for a while. Till I drowned.
Dan: Oh. Well, thanks dad. That's a great story.

Dan: Do you really want to spend the entire summer with me in Rome? Chuck's dad is alive. That is going to change his world deeply.
Blair: His, yes. But not mine.

Dan: Blair's getting married and having a baby with Louis. And if she wasn't with Louis she'd be with Chuck, not me.
Rufus: Maybe. Even if Blair doesn't feel the same way, it might be worth it for you to tell her how you feel. At least so you can move on.

Dan: Blair. What are you doing here? Did Louis—
Blair: I didn't know where else to go. I wasn't going to come here. I haven't talked to you all summer and you're the only person I know in New York right now. And I really need a friend. If you're still...
Dan: Of course I am. What's going on?

Dan: Did you come all the way to Brooklyn just to yell at me? 'Cause that's really not necessary.
Blair: Yes it is.

Hey, Blair, it's Rachel that's been messing with you. And ... we had sex in the costume closet. So, do what you want with that.

What could be friendlier than taking a mock photo?

Serena: Sorry if we kept you up last night. We were playing Scrabble.
Ben: She fell asleep to avoid losing.
Dan: Since when do you enjoy Scrabble?

Um, have you not told Louis because it might be Chuck's?

Serena: I noticed the other day that you don't wear a watch. And then it occurred to me it's because you don't have a watch. You're going to need one to be punctual for all the meetings with editors and publishers, now that you're fancy and, apparently, self-important writer... You don't like it. You want the band changed.
Dan: No! I love the band. I love the whole thing. It's the most amazing watch I've ever seen... but I can't accept this.
Serena: What? Yes, you can. Look, it's more of a gift for me because I had so much fun picking it out for you. You have to.
Dan: Serena, I buy a book for my dad every Christmas. I think the most elaborate gift I've ever given has been a pair of rubber boots from L.L. Bean.
Serena: So, then, I overdid it?
Dan: I think even when you're underdoing it, you're overdoing it.

Dan; You're no one until you're talked about.

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.