"I guess there really is no starting over, is there?"

MARK: "Can I buy you a drink, Dr. Torres?"
CALLIE: [gets up] "Not unless you have it delivered to my hotel room... I'm going to bed. You coming?"

MARK: "Is that your boyfriend again?"
CALLIE: "I do not have a boyfriend."
MARK: "Then why the guilty face?"
CALLIE: "You were sexier when you weren't talking."

MARK: "She told you. I've known you my whole life, I grew up with you so I know what you're thinking. That there is a year of your life wasted. Trying to make it work with Addison and you could have been with Meredith. That you could be happy right now. That all of this, everything... that you and Meredith could have had a real chance. Still, I thought you should know the truth. I thought I owed you that, as a friend."
DEREK: [walks away] "You're not my friend."

MARK: "At least now you don't have to feel guilty anymore."
ADDISON: "Shut up."

MARK: "So we're clear: You knew when you stepped into that surgery you forfeited your future in plastics, right?"
ALEX: "But, Dr. Sloan-"
MARK: "Give me my phone back."

MARK: "Nancy-pants?"
NANCY: [smiles] "Hey loser."
MARK: "I wish Derek told me you were coming to visit."
NANCY: "Oh, like he tells you anything these days."
MARK: "I'm working on that."
NANCY: "What are you doing here, Mark? Are you trying to torture him?"
MARK: "He's my family, Nancy. Plus I needed a change of pace.... Plus I slept with my tennis partner's wife and he bought a gun."
NANCY: "There it is!"

MEREDITH: "Okay, before you start, there are rules to this friendship thing, or whatever."
MARK: "The Dirty Mistresses Club has rules? Gosh, I didn't think a bunch of dirty mistresses would be a little less uptight about these, uh, rules."

MEREDITH: "Number one: No flirting. Second: No talking about Derek and C: No giving me the face."
MARK: "The face?"
MEREDITH: "The McSteamy face. Doesn't work on me. I'm immune."
MARK: "If I'd gone off to the woods, I would've invited you to keep me warm."
MEREDITH: "Breaking rules 1, 2 and 3."

"Start over, Meredith. Start fresh."

"Derek's damaged goods. I know because I'm the one that damaged him. But ask yourself, do you really want to drink out of a poisoned well?"

MEREDITH: "McSteamy! Woo hoo!"
MARK: "McSteamy? That's what you're calling me now?"
MEREDITH: "Yes... but I don't think you are supposed to know that."
MARK: "How's my favorite dirty mistress?"
MEREDITH: "No, now I'm an adulterous whore!"

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey