Sheldon: I've read that there are great yogis who have such mastery over their bodies they can draw water in through their genitals.
Penny: Yeah well I don't think we're going to get to do that today.
Sheldon: Too bad. Seems like a good way to drink a milkshake without getting brain freeze

Sheldon: *whines*
Penny: You want to come with me?
Sheldon: Really?
Penny: Come on boy! Come on! Let's go!

Penny: Why are you sitting in the stairwell?
Sheldon: Leonard told me to stay.
Penny: Oh. Well, good boy.

Leonard: Look, if you want to break up, just say it.
Penny: Leonard....
Leonard: No, no, no, I take it back, don't say it. Just hate me but stay with me. It worked for my parents.
Penny: Listen. I don't want to break up with you.

Penny: Are you going to lay on the floor and pretend to be dead all night?
Stuart: What do you think I'd do at home?

Penny: Translation?
Leonard: Waah. I don't want a table!

Sheldon: No, I've changed. Like the frog who's put in a pot of water that's heated so gradually he doesn't realize he's boiling to death.
Penny: Or you're the frog who's been kissed by a princess and turned into a prince.
Leonard: Or, you're just a tall, annoying frog.

Penny: Who's the murderer?
Raj: Any question but that.
Penny: Sorry ... hey, who's not the murderer?

Sheldon: I have spent years turning this lump of clay into an acceptable conduit for my will, and then you came along and reshaped him, with your newfangled ideas and your fancy genitals.
Penny: Are you gonna let him talk to me like this?
Leonard: "Fancy" sounds like a compliment.

Penny: I can't believe Leonard is spending hundred of dollars on scalped tickets.
Amy: Last week, you spent that on a little dress.
Penny: Yeah, but those tickets only get him into Comic-Con. That dress gets me into anywhere I want.

Penny: Okay, sex is not what makes you a grown-up.
Bernadette: Yeah, or you'd be the oldest one here.
Penny: Really? Is that how you talk to your mother?

Leonard: Plus, I'm not sure it's a great idea to take Penny to where wine comes from. [chuckles] What? It's a joke. Oh, come on. We bust on each other. I wear dorky glasses, you might have a problem -- it's all for laughs.
Penny: That would really piss me off if I didn't have a buzz going on.

TBBT Quotes

Sheldon [to Kripke]: Also, I am given to understand that your mother is overweight.
Raj: Oh, snap.
Sheldon: Now of course, if that is the result of a glandular condition and not sloth and gluttony then I withdraw that comment.

How is "doable" anything but a compliment?

Wolowitz