Like you said, you're a Waldorf. You don't let people tell you who you are, you show them.

Serena: So where's Georgina?
Chuck: You're out of luck, she just left.
Serena: Where's Dan?
Chuck: I'm out of luck, he's still here.

Nate: Don't go with Tripp.
Serena: Nate ...
Nate: Look, I know what I did was wrong. But I did it because ... ever since last week, ever since three years ago when you left ... please don't go. Please stay here with me. Please give me a chance.

Serena: Brown is an Ivy League school.
Blair: Everyone knows that the only REAL Ivies are the holy trinity: Harvard, Yale and Princeton.

Serena: Okay let's get one thing straight. Our parents might be insisting on blending our households but I am not your sister. I do not share any of your DNA, nor do I ever wish to.
Chuck: Then I suggest you get new hand towels.

Serena: I'm sorry, I'm not laughing. It's just so obvious. You're not over Blair. This is your body's way of telling you!
Chuck: I don't have a romantic bone in my body. Least of all that one. But you do raise an interesting idea. Clearly there's some kind of ... blockage.
[pauses] Perhaps ...
Serena: No!
Chuck: One more go-around, just to clear the pipes.
Serena: You are not using Blair as sexual Drano!

Chuck: Yale, the only thing she wanted more than me. That would be painful.
Serena: Chuck, she's embarrassed, so we've gotta give her time to lick her wounds.
Chuck: Maybe I could lick them for her.

I killed someone.

Serena: Blair?
Blair: Serena, what are you doing here? It's late. Oh my God. What's happened? What's wrong? Talk to me.
Serena: I can't.
Blair: Of course you can.
Serena: No. No, B, this is the one thing I can't tell you. I can't tell anyone.
Blair: I'm not anyone, I'm me. You can tell me anything.
Serena: No I can't. Because then that would make you a part of it. And you can't be a part of this.
Blair: What are you talking about? You're starting to scare me. Hey, hey, hey. We're sisters. You're my family. What is you, is me. There's nothing you could ever say to make me let go. I love you. What is it?

Maureen: You can have him in private, I get him in public. He keeps his career, I keep my reputation. You get ... whatever it is you're getting. Screwed, I think they call it?
Serena: You're offering me the chance to be your husband's mistress?
Maureen: It's a time-honored political tradition. I'm Jackie. You're Marilyn.

Blair: Remember, Serena doesn't share!
Serena: Remember, Blair should learn to.

Chuck: The reason Blair attacked you is because she misses you. After 18 years, you can't read Waldorf subtext?
Serena: I shouldn't have to. If that's how she feels then she should just tell me. It's the mature thing to do.
Chuck: This coming from someone who just pushed their best friend into a cake.

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.