Can you just get it over with, Chuck? Say whatever pervy thing you're going say and leave.

Serena: B, what are you doing?
Blair: Giving home schooling some serious consideration.

Serena: So do you think Jenny'll be alright?
Nate: Yeah, Dan's a good guy, he'll take care of her.
Serena: You are too, you know, a good guy. A forgiving guy?
Who can't pit himself against Blair forever?
Nate: Goodnight.
Serena: I'm sorry! You gave me an opening I couldn't resist... I'm just saying.

Serena: Okay let's get one thing straight. Our parents might be insisting on blending our households but I am not your sister. I do not share any of your DNA, nor do I ever wish to.
Chuck: Then I suggest you get new hand towels.

You're right, Mom. This morning I woke up feeling a little uneasy and thought to myself "Hmm, maybe I'll call the entire junior class out to the courtyard for a little champagne toast."

Blair: How do you manage to get out of everything unscathed?
Serena: Because I'm nice. You should try it. Come on, compliment me, tell me my hair looks beautiful.
Blair: But your hair looks disgusting. Did you even shower today?

Serena: What are you doing?
Eric: I'm hiding from my valet. He wanted to put my socks on for me this morning. Your servants are very attentive.
Chuck: You should meet Bergita the maid.
Serena: No! No he should not meet Bergita, he's 14. Ignore this person.
Chuck: May I remind you, Serena, that you used to have a sense of humor.

Serena: What is your problem?!?
Chuck: Specify the context.

Like you said, you're a Waldorf. You don't let people tell you who you are, you show them.

Eric: Is there something you want to tell me?
Serena: I'm that obvious? Yes, actually. That hair color is all wrong for you.
Eric: That's funny. This isn't.

Random Student: Hey, mom!
Serena: Yes! I'm pregnant and it's yours!

Serena: And you're acting like a total bitch because you're not hormonal?
Blair: Maybe I am a total bitch. Ever think about that?
Serena: Take the test, B.
Blair: Stop it.
Serena: Take the test. We need to know if you and Chuck are going to have a baby.

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.