Fitz: What was in the case Jemma?
Simmons: Something to help Skye.
Fitz: Because you want to change her; is that it?
Simmons: Stop it. I don't want to change Skye, the Diviner did that. I'm just trying to fix her.

Coulson: I'm sorry about everything that's happening Skye.
Skye: Not your fault. The blame begins and ends with my dad.
Coulson: Well, you wouldn't be the first person to have parents with misguided intentions.
Skye: Nope, just the first whose crazy dad lured her to an alien city to get earthquake powers.
Coulson: Yeah.

Bobbi: Everything I felt for you, that was real.
Hunter: Yeah maybe so, but in the end you still got that intel didn't you?

This is not a decision that we arrived at lightly. I know Coulson, he was a good agent. At least he was before Fury injected him with alien DNA. Ever since, his behavior has grown increasingly more troubling. Can you honestly tell me that you don't share any of these concerns?

Gonzales

Fitz: Things change, that's what I'm saying, so maybe if you can learn to control this then you could have Avengers level powers. Something like Captain America even.
Simmons: I think it best we keep in mind the unstable nature of Skye's power. If there is an Avenger equivalent right now, I'm afraid it's the Hulk.
Fitz: Well, Hulk saved the world last I checked.

Fitz: I won't stay long, I just need to use the microwave. I didn't want to disturb May and her ex.
Simmons: Disturb them from?
Fitz: They're in the kitchen, talking.
Simmons: What are they talking about? Is it about Skye's condition?
Fitz: No it was of a personal nature. Seems that May isn't a good cook.
Simmons: Something Agent May doesn't excel at; interesting.
Fitz: Yeah, he teased her about it. She was laughing.
Simmons: Aw he makes her laugh. Clearly she still likes him and have you seen the way he looks at her?
Fitz: Yeah I have eyes Jemma, of course I've seen.
Simmons: I wonder what happened between them, why end it?
Fitz: They're a bizarre pair. He listens for a living and she doesn't speak.

Dr. Garner: I'm not here to discuss my ex.
Skye: Did you guys have actual conversations? You know like pillow talk? Or was it just pillow stern looks?

We're spies, we lie for a living.

Bobbi

Dr. Garner: I haven't worked with S.H.I.E.L.D. in a long while. I moved on for a reason.
May: It's a different S.H.I.E.L.D., Coulson's the director now.
Dr. Garner: Okay, but why me? Is this Skye that bad?
May: She's that good; good agent.

My entire life I've been searching for my parents, and my search ended with answers that are so much worse than I could have imagined.

Skye

Coulson: You agree with her. You think Skye is more than we can handle.
Agent May: Look, most of the time, I believe what I see, you know that but...
Coulson: But?
Agent May: You died. You were brought back, with a map to a city encoded in your DNA. Our team's first mission.
Coulson: We picked up Skye.
Agent May: Last week, we took her to that city. I can't help but remember what Lumley said. Wherever Skye goes...
Coulson: Death follows.

Coulson: Are you talking about fate?
Lady Sif: I am saying there are tides in the universe that you can not swim against.

Agents of S.H.I.E.L.D. Quotes

The world is full of evil, lies, pain, and death and you can’t hide from it. You can only face it. The question is when you do, how do you respond, who do you become?

Coulson

Hill: Then New York was invaded by aliens, and they were beaten back by among others, a giant green monster, a costumed hero from the 40s, and a god.
Ward: I don't think Thor is technically a god
Hill: You haven't been near his arms.