"To be a good surgeon you have to think like a surgeon. Emotions are messy. Tuck them neatly away and step into a clean sterile room where the procedure is simple. Cut, suture, and close. But sometimes you’re faced with a cut that won’t heal. A cut that rips its stitches wide open. They say that practice makes perfect."

MEREDITH

[to Meredith] "So I go upstairs, preparing myself for what I'm going to see when I walk into my bedroom. I step on a man's jacket that doesn't belong to me. Then everything I know... it just shifts. Because what I know now is that when I go into my bedroom, I'm not just going to see that my wife is cheating on me. I'm going to see that my wife is cheating on me with Mark, who happens to be my best friend."

DEREK

DEREK: "Meredith, I understand..."
MEREDITH: "Do you? Somehow I doubt it. Because if you did, you would shut up, turn around and go back inside, because you would realize that I am this close to getting in my car and running you over in the parking lot!"

"You know what happens to pregnant interns. I'm not switching to vagina squad or spending my life popping zits. I'm too talented. Surgery is my life."

CRISTINA

PRESTON: "So what's the story with you and Grey?"
DEREK: [pauses] "I got drunk and she took advantage of me. Or she got drunk and I took advantage of her. Well, either way, we were drunk, definitely, and somebody took advantage. I look at it as my initiation into Seattle. What about you?"
PRESTON: "I don't have a story, I just wanted to hear yours."

PRESTON: "What do you want?"
CRISTINA: "What..."
PRESTON: "What do you want? You don't want to go out to dinner. You don't want to meet me in the on call room, and you sure as hell don't want to talk to me. I could pretend that I know, but hey, I don't even have your home phone number. So what do you want!?"

DEREK: "Addison, what are you doing here?"
ADDISON: "What are YOU doing here? You left everything -- your house, your wife, your practice. You had a life. Now you have a girlfriend in Seattle. She seems... sweet."

ADDISON: "Am I interrupting?"
RICHARD: "You're never interrupting."
DEREK: "She's always interrupting."

RICHARD: "You and I both know she's the best in the field. Bringing Addison out was a business decision. It's nothing personal."
DEREK: "Oh, well, that's a relief. Not personal. It's personal to me!"

"Surgery is the only specialty at the hospital where we don't waste time getting to know the patients. They're slabs of meat, and we're butchers."

ALEX

MEREDITH: "Lip gloss. I wore my new lip gloss because my ex-boyfriend's wife looks like Isabella freaking Rossellini and I'm like, me. I'm trying to outdo her when she's the victim here. How crazy is that?"
GEORGE: "It's not that crazy, you know... smart. Lip gloss prevents chapped lips. You... was that ex-boyfriend?"
MEREDITH: "I am an evil mistress."
GEORGE: "But still... you look nice."

MEREDITH: "You're sleeping with someone?"
GEORGE: "What? You are? Who?"
CRISTINA: "What? Why is that such a shock? Even George managed to get some action."
GEORGE: "Um, Correction! George got some syph."

Grey's Anatomy Season 2 Episode 1 Quotes

MEREDITH: "So that's it? Was that what I was to you? The girl you screwed to get over being screwed?"
DEREK: "You were like coming up for fresh air. It's like I was drowning and you saved me. That's all I know."
MEREDITH: [pauses] "That's not good enough."

MEREDITH: "I don't believe it. After all this time, and all your warnings about me sleeping with my boss, you're doing the same exact thing."
CRISTINA: "Oh, it's not the same thing."
MEREDITH: "It's the exact same!"
CRISTINA: "No, it's not. Not at all. You and McDreamy are in a relationship."
MEREDITH: "And you and Burke are in-"
CRISTINA: "Switzerland. You should go there! It's very neutral and they make very nice watches."