Mark Sloan never loses it in the ER. Not ever.

Addison

Turns out your stupid Post-It is 10 times the marriage my church wedding ever got to be. I'm moving on.

Alex

[to Mer] You gonna look me in the eye and tell me Derek never threw a cranionomy after the two of you spent an hour in the on-call room? Please.

Alex

I'm in the middle of a divorce. People call me the Nazi, and it's not because of my ice blue eyes. I spend 12 hours a day carving people up, and I like it. I have a child and I have no room for casual anything. I'm angry all the time. ... You want lunch, or you wanna show me the scan?

Bailey

[to Alex] Let me scrub in and I'll take you out to drinks afterwards and, you know...

Reed

Addison: You told her?
Mark: She's my kid. We were bonding.
Addison: That's now how you bond with children.
Mark: I'm still getting the hang of it.

[to Der] You wouldn't be starting a conversation about my personal life, would you? Bad idea? Bad idea!

Bailey

Addison: Let me say it once: Grandpa... Grandpa, grandpa, grandpa!
Mark: Okay. That was four times. Get it out of your system?

Get me Addison Montgomery!

Mark

Ask any physician and they can point to the one moment they became a surgeon.

Meredith

I'm a surgeon and I'm looking at a time bomb in a uterus. Shut it down now, Addison!

Mark

Mark: It's the guilt, you know? It's like every time I look at her... I just... The guilt is like a punch in the gut. Everyday.
Derek: Well, you shouldn't feel guilty, you didn't know.
Mark: I did know. I knew it when her mom got pregnant. She told me. I gave her a couple hundred bucks and I left town and I never saw her again. I figured she got an abortion. Hoped. But I did know.
Derek: Well you're a different guy now. You're not 18 anymore, you've grown up, and you're capable of better.

Grey's Anatomy Season 6 Quotes

In medical school, we have a hundred lessons that teach us how to fight off death, and not one lesson on how to go on living.

Meredith (narrating)

According to Elisabeth Kubler-Ross, when we're dying or have suffered a catastrophic loss, we all move through five distinct stages of grief. We go into denial because the loss is so unthinkable we can't imagine it's true. We become angry with everyone, angry with survivors, angry with ourselves. Then we bargain. We beg. We plead. We offer everything we have, we offer our souls in exchange for just one more day. When the bargaining has failed and the anger is too hard to maintain, we fall into depression, despair, until finally we have to accept that we've done everything we can. We let go. We let go and move into acceptance.

Meredith (narrating)