Mark Sloan never loses it in the ER. Not ever.

Addison

Turns out your stupid Post-It is 10 times the marriage my church wedding ever got to be. I'm moving on.

Alex

[to Mer] You gonna look me in the eye and tell me Derek never threw a cranionomy after the two of you spent an hour in the on-call room? Please.

Alex

I'm in the middle of a divorce. People call me the Nazi, and it's not because of my ice blue eyes. I spend 12 hours a day carving people up, and I like it. I have a child and I have no room for casual anything. I'm angry all the time. ... You want lunch, or you wanna show me the scan?

Bailey

[to Alex] Let me scrub in and I'll take you out to drinks afterwards and, you know...

Reed

Addison: You told her?
Mark: She's my kid. We were bonding.
Addison: That's now how you bond with children.
Mark: I'm still getting the hang of it.

[to Der] You wouldn't be starting a conversation about my personal life, would you? Bad idea? Bad idea!

Bailey

Addison: Let me say it once: Grandpa... Grandpa, grandpa, grandpa!
Mark: Okay. That was four times. Get it out of your system?

Get me Addison Montgomery!

Mark

Ask any physician and they can point to the one moment they became a surgeon.

Meredith

I'm a surgeon and I'm looking at a time bomb in a uterus. Shut it down now, Addison!

Mark

Mark: It's the guilt, you know? It's like every time I look at her... I just... The guilt is like a punch in the gut. Everyday.
Derek: Well, you shouldn't feel guilty, you didn't know.
Mark: I did know. I knew it when her mom got pregnant. She told me. I gave her a couple hundred bucks and I left town and I never saw her again. I figured she got an abortion. Hoped. But I did know.
Derek: Well you're a different guy now. You're not 18 anymore, you've grown up, and you're capable of better.

Grey's Anatomy Season 6 Quotes

[narrating] The human life is made up of choices. Yes or no. In or out. Up or down. And then there are the choices that matter. Love or hate. To be a hero or to be a coward. To fight or to give in. To live. Or die. Live or die. That's the important choice. And it's not always in our hands.

Derek

Burke was- He took something from me. He took little pieces of me, little pieces over time, so small I didn't even notice, you know? He wanted me to be something I wasn't, and I made myself into what he wanted. One day I was me Cristina Yang, and then suddenly I was lying for him, and jeopardizing my career, and agreeing to be married and wearing a ring, and being a bride. Until I was standing there in a wedding dress with no eyebrows, and I wasn't Cristina Yang anymore. And even then, I would've married him. I would have. I lost myself for a long time. And now that I'm finally me again, I can't. I love you. I love you more than I loved Burke. I love you. And that scares the crap out of me because when you asked me to ignore Teddy's page, you took a piece of me, and I let you. And that will never happen again.

Cristina