Oh, and hookups are good. But just to be clear... when you say your "sista," do you mean your sister or your friend?

Mac

Also, first thing we gotta do is get rid of these shamrocks. 'Cause nothing scares Gays and Black folks like Irish crap, you know whadda I mean?

Terrell

Sweet Dee: How could you not tell me you were gay?
Terrell: I'm a musical theater actor!

(After Charlie is caught saying the N word by the Waitress)
Waitress: Wow, nice.
Charlie: No, no. That's not what I was saying.
Waitress: Coffee? Hitler?
Charlie: No, I'm not, not Adolf Hitler.
Waitress: I'll make sure to put a lot of cream in yours.

Mac: Why do these people like you guys so much?
Charlie: Well dude, it's not that they like us, they don't like you! You know why? Uhhh, because you're an asshole!

Dennis: Our mortgage is due in two weeks.
Mac: No, we paid that, like, a week ago.
Dennis: No. A week ago was three weeks late.

(After Charlie throws away a girl's number)
Mac: Whoa, whoa, whoa, whoa. What are you doing, dude?
Charlie: What?
Mac: What are you doing?
Charlie: Ah.
Mac: That girl is gorgeous. She's like the perfect opportunity to show that we are not racist. She probably has friends for me.
Charlie: Well, come on. If anything, I think we should be focused on black men, first of all.
Mac: What?!

I hate listening to people's dreams. It's like flipping through a stack of photographs. If I'm not in any of them and nobody's having sex, I just don't care.

Dennis

Dennis: It's because of those bison fingers.
Dee: I do not have bison fingers!
Frank: Yeah you do. Your mother had to have a c-section because of those hands.

Dee: Who slams a door?
Frank: Babies.
Dennis: That guy has some real growing up to do. Have some repect for Christ's sake... I am legend.

What's going on is that you just drank a cup of poison.

Charlie

Charlie: I'll totally pull a Good Will Hunting on those kids and that'll put them in their place.
Mac: How you gonna do that?
Charlie: Well, you've seen the movie right?
Mac: Yeah.
Charlie: So all I gotta do is, I'll ask them some big shot, like math or science, history-type college question aand that will totally stump them by knowing a lot more about the answer than they do.
Mac: In that movie, Matt Damon played a genius janitor, you're just a janitor.
Charlie: Right, you stumped me with that one.

It's Always Sunny Quotes

Charlie: I'll totally pull a Good Will Hunting on those kids and that'll put them in their place.
Mac: How you gonna do that?
Charlie: Well, you've seen the movie right?
Mac: Yeah.
Charlie: So all I gotta do is, I'll ask them some big shot, like math or science, history-type college question aand that will totally stump them by knowing a lot more about the answer than they do.
Mac: In that movie, Matt Damon played a genius janitor, you're just a janitor.
Charlie: Right, you stumped me with that one.

Mac: He doesn't have any poison.
Charlie: I don't have any on me, but I do keep some in my fridge at home in the relish jar.
Frank: There's poison in that jar? I thought I was allergic to pickles. What's in the jar with the skull and crossbones?
Charlie: Well that's mayonnaise. It's a decoy.
Frank: And the mayo?
Charlie: That's shampoo.
Frank: You're telling I've been putting shampoo on my sandwiches?
Charlie: If you've been using the mayonnaise, then yeah, probably.