Bailey is the first to welcome Addison back to Seattle Grace. Inside, she has an awkward reunion with Meredith and Derek. Mark propositions her for sex. Ah, it just feels like home.
Izzie finds out her interns were at a party at George and Lexieâ€™s the night before without her knowledge. The hikers from last week are back and Meredith decides to start her clinical trial on the patient with the brain tumor. Ava/Rebecca shows up, pulls Alex aside, and blurts out that sheâ€™s pregnant.
All in the first couple of minutes!
Miranda and Addison, after catching up, prepare two young parents for the surgery theyâ€™re about to do on their unborn child, which is growing a heart on the outside of its body.
Meredith Greyâ€™s (Ellen Pompeo) patient keeps yelling out in appropriate things because of his tumor. He then bursts out laughing, saying that he canâ€™t see anything and heâ€™s blind. Derek (Patrick Dempsey) warns Meredith not to get attached to the patients involved in her clinical trial.
Meredith stops into her therapist's office, quickly vents about Derek, and heads back out to prepare for surgery. The man with the tumor tells his wife to find happiness if he doesn't make it through the surgery. Later, Derek and Meredith inject a virus directly into the patient's tumor. Meredith and Derek eventually lose their patient.
Ava/Rebecca (Elizabeth Reaser) keeps paging Alex (Justin Chambers) to talk things out with him but he refuses to even enter into a conversation with her.
Addison confronts Callie (Sara Ramirez), asking if she's in a relationship with Erica (Brooke Smith), who starts freaking out at the question. The baby that Addison was working on then begins hemorrhaging.
Izzie informs a couple that they're pregnant but they immediately break down and say they need an abortion. The mother reveals that she's HIV-positive and wants to proceed with the abortion.
Izzie tries to convince the couple they can have a healthy baby but the mother tells Izzie to schedule it and not to come back - she wants a different doctor.
George tells Izzie (Katherine Heigl) the truth that the interns don't want to hang out with her because she's the boss. She tells the two parents there is a 98 percent chance their baby will be born healthy.
Dr. Hahn lets Cristina in on the surgery at Callie's request. She massages the baby's heart as they get him stabilized. The surgery is successful thanks to Hahn, Sloan, Bailey, Addison, Alex, and Cristina.
Miranda finally opens up to Addison, telling her Tucker moved out but she won't talk about it. Richard tries to get Addison to come back for good, but we know that's not to be.
In a lighter moment (for everyone but him) Derek ends up riding an elevator with Meredith, Addison, and Rose (Lauren Stamile) all at the same time. Amused Mark gets on next, sees the awkwardness and chides friend.
Cristina finally confronts Erica about why she ignores her. The answer from the cardio-god is actually rather simple: stop seeking her approval.
At the bar, Addison (Kate Walsh) lectures Meredith for letting Derek slip away, then realizes that Erica's in love with Callie - who makes a rather bold move by leaving with Mark. Izzie discovers Rebecca is, in fact, not pregnant and was lying to get Alex's attention.
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