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When Wolowitz gets a phone call from Leslie, dumping him as friends with benefits, he starts crying. Apparently, Wolowitz got a little emotionally attached in his unemotional relationship. Sheldon suggests they go to Vegas.. the city designed to help people get away form their problems and form new ones. Leonard, Raj and Wolowitz all decide they want to go! Sheldon, despite suggesting it, chooses not to and the guys are more than happy not to have him along.
They arrive in Vegas, but Wolowitz refuses the leave the room. Wolowitz wants to spend the night in the room stalking Leslie on Facebook and Twittering his life. Raj and Leonard head to the bar where they get approached by a prostitute. Once they realize what she is, they decide to hire her to cheer up Wolowitz and even pretend to be Jewish. They lure Wolowitz down with the promise of shrimp the size of babies' arms. The prostitute immeditately begins her work and despite Wolowitz realizing what she is, he's thrilled with what the guys did.
Meanwhile, Sheldon is left home alone and can't wait to spend the weekend in his fortress of solitude. He realizes he left his keys in his apartment, and Penny invites him over to eat his dinner there while they wait for the building manager to come and unlock it for him. When the manager doesn't come, Sheldon spends the night there.. kicking Penny out of her bed and generally annoying her. Anyone else would have found this the ultimate night as opposed to ruining his plan to be alone.