A great scene from the second episode of the first season, "The First Cut is the Deepest."
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The opening three minutes of the Grey's Anatomy pilot, "A Hard Day's Night." Features narration from Dr. Meredith Grey, a surgical intern and the program's title character. The clip also features a certain Dr. McDreamy she brought home the night before....
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Grey's Anatomy Season 1 Quotes

[narrating] "At some point, you have to make a decision. Boundaries don't keep other people out, they fence you in. Life is messy, that's how we're made. So you can waste your life drawing lines or you can live your life crossing them. But there are some lines that are way too dangerous to cross. Here's what I know. If you're willing to throw caution to the wind and take a chance, the view from the other side... is spectacular."

MEREDITH

DEREK: "It's not the chase."
MEREDITH: "What?"
DEREK: "You and me. It is not the thrill of the chase. It's not a game. It's... it's your tiny ineffectual fists. And your hair."
MEREDITH: "My hair?"
DEREK: "It smells nice. And you're very, very bossy. It keeps me in line."
MEREDITH: "I'm still not going out with you."
DEREK: [smiles] "You say that now."