Gossip Girl Spoilers: Major Breakup Ahead, Juliet to Blame!

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What's on tap for our favorite Upper East Side crew in the coming weeks?

Let's just say Juliet's meddling in "The Undergraduates" was just the start.

"Something wicked comes their way," EW reports this morning, and you can point the finger at Katie Cassidy. "Juliet’s butting in is going to lead to a major couple breaking up."

Chace Crawford and Katie Cassidy Picture

What's Juliet's grand plan and who will bear the brunt?

How will Juliet's agenda, whatever it might be, set a couple's breakup in motion? Which pair is it, and how will it come about? Theories and comments are encouraged below.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Gossip Girl Quotes

And who am I? That's one secret I'll never tell ... You know you love me. XOXO, Gossip Girl

Gossip Girl

[to Jenny] That's the thing. You need to be cool to be queen. Anne Boleyn thought only with her heart and she got her head chopped off. So her daughter Elizabeth made a vow never to marry a man. She married a country. Forget boys. Keep your eye on the prize, Jenny Humphrey. You can't make people love you, but you can make them fear you. For what it's worth, you're my Queen. I choose you.