The final season of One Tree Hill is off and running.

On this week's new episode, look for Brooke and Julian to awaken with a startle and a fear that their children are gone. But the reality of their situation will prove to be far worse, as depicted in this clip from "In the Room Where You Sleep."

Elsewhere on the installment...

• Quinn will convince Clay to get help.
• Millie will struggle with honesty when it comes to Mouth.
• Nathan takes off for Europe, leaving Dan alone with Haley and Jamie.

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.