Simon Helberg stars as Howard Wolowitz, the only one of the nerds that is not a doctor. He is an engineer at Caltech and is friends with Leonard and Sheldon and frequently is over at their apartment. Wolowitz mostly goes by his last name and still lives with his mother.
Most jokes with Wolowitz revolve around his failed attempts at womanizing, though he was given a girlfriend, Bernadette, in season three.
[Raj whispers in Wolowitz's ear]
Penny: What did he say?
Wolowitz: He compared Sheldon to a disposable feminine cleansing product one might use on a summer's eve.
Penny: Yeah, and the bag it came in
Raj: I know. Being an astrophysicist right now is like being a rock star.
Howard: Only without the sex.
Raj: Yeah, literally, none of it.