Lisa Marie Simpson, voiced by Yeardley Smith, is Homer and Marge's oldest duaghter and the middle child on The Simpsons.  Lisa is very intelligent, plays the saxophone, is a vegetarian, Buddhist, and definitely a bit of a young political activist.  She's basically the complete opposite of her brother, Bart.

Lisa Simpson Quotes

Lisa: I'll study so hard I'll make the old me look like Bart.
Homer: That'd be one weird looking kid.

Bart: Lower the draw bridge!
Lisa: What's the password?
Bart: (slowly) I love my sister.

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The Simpsons Quotes

Dearest Edna, I must leave you. Why, I cannot say. Where, you cannot know. How I will get there, I haven't decided yet. But one thing I can tell you, any time I hear the wind blow it will whisper the name Edna. And so let us part with a love that will echo through the ages. ---Woodrow

"Woodrow"

Mr. Burns: (reading Homer's letter) "Dear Mr. Burns. I'm so glad you enjoyed my son's blood, and your card was just great." Why Simpson, you've made my day, you're a true gentlemen.
Homer: Well I-
Mr. Burns: Hello, there's more. (continues reading) "In case you can't tell, I'm being sarcastic. You stink! You are a senile bucktoothed old mummy with bony girl arms and you smell like an elephant's butt!"