Lisa Marie Simpson, voiced by Yeardley Smith, is Homer and Marge's oldest duaghter and the middle child on The Simpsons.  Lisa is very intelligent, plays the saxophone, is a vegetarian, Buddhist, and definitely a bit of a young political activist.  She's basically the complete opposite of her brother, Bart.

Lisa Simpson Quotes

Nevada makes my butt look big.

Lisa

Ooh, an institute!

Lisa
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The Simpsons Quotes

Bart: I'll go, disguised as you.
Lisa: What if he wants to hold hands?
Bart: I'm prepared to make that sacrifice.
Lisa: What if he wants a kiss?
Bart: I'm prepared to make that sacrifice.
Lisa: What if he
Bart: You don't want to know how far I'll go.

Homer: (Wearing glasses) The sum of the square roots of any two sides of an isosceles triangle is equal to the square root of the remaining side!
Man: (From inside a bathroom stall.) That's a right triangle, you idiot!
Homer: D'oh!