Agent Fitz struggled with, but overcame the damage to his brain after suffering oxygen deprivation at the hands of Ward. He was the last person to see Simmons. Will he blame himself for her mysterious disappearance?

Fitz will not stop until he discovers the truth behind Simmons' disappearance. Can he find some answers regarding the massive alien Kree monolith? Who will he turn to for help, Lady Sif perhaps?

As for poor Simmons, is she inside that Kree monolith or did it teleport her elsewhere? Will its unknown properties somehow alter her physically? Perhaps even giving her powers of her own?

Simmons proved to be quite fearful of the Inhumans last season. If/when she reappears, will Simmons play nice with the new superpowered folks? Or will she turn to the ATCU (Advanced Threat Containment Unit) for help?

Mack and Coulson definitely clashed last season, as he didn't feel the Director was acting in S.H.I.E.L.D.'s best interest. After saving Coulson's life, their relationship seemed to change for the better.

Season 3 finds Mack working alongside Coulson and Daisy to build a stronger team, that includes both highly skilled Agents of S.H.I.E.L.D. and powered individuals.

Superspy Bobbi took quite a beating from Ward last season. Will she recover from the torture Ward inflicted and set her sights on bringing the traitor down? Hey, at least she's got Hunter on her side.

Which reminds me, the Bobbi/Mockingbird & Lance Hunter spinoff is back on. Are you looking forward to exploring the further adventures of these two on Marvel's Most Wanted? Will Ward make an appearance on the new show?

Hunter had quite a journey last season, starting off as an indifferent mercenary and becoming a loyal addition to the team. What do you make of his relationship with Bobbi? It seems the duo will be working closely together this season.

With so many different threats looming, it's possible S.H.I.E.L.D. will splinter off into Secret Warriors and Marvel's Most Wanted. One group will handle the Inhuman threat, while Bobbi and Hunter go after Hydra. What do you think?

Lincoln proved himself not only a wonderful mentor to Skye, but a powerful ally fighting alongside S.H.I.E.L.D. It's important that Coulson have an experienced "gifted" individual on his team, and who better than Lincoln?

Patton Oswalt as Agent Koenig on Marvel's Agents of S.H.I.E.L.D.