Sheldon reacts badly when he finds out he had to work with Barry Kripke on The Big Bang Theory. "The Cooper/Kripke Inversion" is the 14th episode of the show's sixth season.
Sheldon [to Kripke]: Also, I am given to understand that your mother is overweight. Raj: Oh, snap. Sheldon: Now of course, if that is the result of a glandular condition and not sloth and gluttony then I withdraw that comment.