Dean: Dude, he's short.
Sam: Hey, Gandhi was a great man.
Dean: For a Smurf.

Dean: Is that Gandhi?
Sam: Yeah!
Dean: Dude, he's squirelly.

Dean: Let me get this straight. Your, uh, ultimate hero was not only a short man in diapers, but he was a fruitarian.
Sam: That's not the point.
Dean: That is good. Even for you, that is good

Dean: Not a word.
Sam: Dude, you just got whaled on by Paris Hilton.

I'm Agent Bonham, this is Agent Copeland.

Sam: Dude, what the hell?
Dean: I had a hunch I went with it.
Sam: You risked my ass on a hunch?
Dean: You're fine. Besides now we know who's turning this town into Willy Wonka's worst nightmare.

Dean: Yeah, everything Jesse believes comes true. He thinks the Tooth Fairy looks like Belushi, uh, joy buzzers really shock people, boom that's what happens.
Sam: Yeah, but convince him that joy buzzers don't actually work and they go from killer machines back into crap toys.
Dean: Probably doesn't even know he's doing it. How is he doing it?

Sam: Oh, d-dude... that's not what I think it is, is it?
Dean: I got bored. That nurse was hot.
Sam: You know you can go blind from that, too.

Jesse: What, didn't your dad tell you about the Tooth Fairy?
Dean: My dad? My dad told me different stories

Castiel: (sits on a whoopee cushion) That wasn't me.
Dean: Who put that there?

Sam: Have you seen you? You look like...
Dean: ... the old chick in Titantic. Shut up.

Dean: Do I know you?
Becky: No, but I know you.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean