CRISTINA: "There's a club. The Dead Dads Club. And you can't be in it until you're in it. You can try to understand, you can sympathize. But until you feel that loss... My dad died when I was nine. George, I'm really sorry you had to join the club."
GEORGE: "I... I don't know how to exist in a world where my dad doesn't."
CRISTINA: "Yeah, that never really changes."

Cristina: I have five rules. Memorize them. Rule number one, don't bother sucking up. I already hate you, that's not gonna change.
Izzie: Traumas protocol, phone lists, pagers. The nurses will page you, you answer every page at a run. A RUN! That's rule number two... You're supposed to follow me!
Alex: The first shift starts now and lasts 36 hours. You're grunts, nobodies, the bottom of the surgical food chain. You run labs, write orders, work every second night until you drop. And you don't complain.
Meredith: On call rooms. Sleep when you can, where you can. You know, but not with anybody. Not attendings, especially not attendings. Sleeping with attendings, not a good idea. Where was I?
George: Er, rule number three. If you're sleeping, do not wake you unless the patient is actually dying.
Cristina: The dying patient better not be dead when I get there, because not only will you have killed someone, you will have woken me for no good reason. Are we clear? Yes?
Lexie: That was four rules. You said five.
Cristina: Rule number five. When I move, you move... Go!

MEREDITH: [to Derek] "I am a sink with an open drain, and anything you say runs straight out." [storms off]
GEORGE: "She probably could have used a better metaphor."
IZZIE: "Give her a break, she's got a hangover."

You know, whenever anyone says something really funny and I laugh I always look around to see if you think it's funny too. Even when you are not there, I look around.

MEREDITH: "How weird is this job?"
GEORGE: "Weird."

Izzie: You read more journals and do more research, and log more hours in the skills lab than any other resident here. You never give up on trying to be a better doctor, and you don't step on other people to do it. I would be lucky to be the new you.
George: Are you gonna tell me about patient X?

IZZIE: "Callie slept with Sloan?"
GEORGE: "I don't get you people."
MEREDITH: "Us, with the boobs? We make alot of bad decisions."

Izzie (to the interns): You want to take narrow slices with the scan so you get a more comprehensive look. What do you see?
George: I see a crazy person taking expensive tests for no reason and, oh, I see the Chief finding out and expelling the crazy person. And then I see joblessness, homelessness and depression. It does not look good, Izzie.

GEORGE: "Izzie."
IZZIE: "George."
GEORGE: "What the hell happened last night? Did I at least call Callie before I passed out?"

Izzie: I'm in love with this incredible guy and we're having problems. And my best friend, he would know what to say to me about it. I need to be able to talk to my best friend. I cannot get through this without my best friend.
George: Why isn't this easier?
Izzie: I don't know.
George: Well, I want my best friend back.
Izzie: Me too.

GEORGE: "You know, you can't say that you weren't warned. Alex has always been Alex."
MEREDITH: "You dodged a bullet, Izz. You're better off without him."
CRISTINA: "Why are you even surprised? You sleep with a snake, you get bit."
IZZIE: "Thanks, guys... for the support."

GEORGE: "She just smiled at me!"
IZZIE: "A, this is not a competition. And B? My quint kicks your quints' asses."

Grey's Anatomy Quotes

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)