"When Derek broke up with you, nobody told you were better off without him. It's not supportive, it's condescending. I was there for you, and the one time I need you? Just go away, Meredith."

IZZIE

• Permalink: When Derek broke up with you, nobody told you were better off w...
• Added: July 24, 2006

DEREK: "The first person I killed? I was a second-year resident. James Hanson. Go home, Dr. Karev. There's nothing you can do for him now."
ALEX: [pauses] "No one should die alone."

• Permalink: The first person I killed? I was a second-year resident. James ...
• Added: July 24, 2006

[to Alex] "Look, you screwed up. Mr. Martin's fried. He wakes up, you fried his brain. He dies, you killed him. Deal with it."

DEREK

• Permalink: Look, you screwed up. Mr. Martin's fried. He wakes up, you fri...
• Added: July 24, 2006

IZZIE: "I'm telling you, Meredith was all over him."
CRISTINA: "Seriously, she was all over him? What, like mounting him, with all the babies watching? Seriously?"
IZZIE: "Well, she would have if I hadn't interrupted."
GEORGE: "She was talking to him."
IZZIE: "You don't talk to bastards who cheat on their girlfriends, George. That's the rule."
GEORGE: "You weren't officially his girlfriend."
IZZIE: "That's not the point."
GEORGE: "It is kind of the point. You don't see me getting all emotional over people I'm not dating."
IZZIE: "Really. You wanna go there?!"
GEORGE: [pauses] "No."
IZZIE: "I'm having a moment here. Don't mess with me!"
CRISTINA: "You're not going to have a nervous breakdown and kill yourself, are you?"
IZZIE: "No."
CRISTINA: "So, there's no chance you'll kill us?"
IZZIE: [storms off]
GEORGE: [tries to hide smile] "Okay, that was wrong on so many levels."
CRISTINA: "But it was good though?"
GEORGE: [laughs] "Yeah, it was."
CRISTINA: [laughs]

• Permalink: I'm telling you, Meredith was all over him. Seriously, she wa...
• Added: July 24, 2006

"You're not here to make friends, Addison. You're here to make better surgeons. Being a teacher can be a lonely business."

RICHARD

• Permalink: You're not here to make friends, Addison. You're here to make b...
• Added: July 24, 2006

OLIVIA: "He dumped me for a girl he knows he can't have. Listen to me George. You, Meredith Grey? Never going to happen."
GEORGE: "Why, why, why would you even... why? Meredith?"
OLIVIA: [storms out]
GEORGE: [to patient] "She gave me syphilis."

• Permalink: He dumped me for a girl he knows he can't have. Listen to me Ge...
• Added: July 24, 2006

[to George, Olivia] "You know what time it is? Time for you two kids to kiss and make up, that's what time it is!"

PATIENT

• Permalink: You know what time it is? Time for you two kids to kiss and ma...
• Added: July 24, 2006

CONSTANCE: "He said he would leave me if I didn't help him. Things got out of control. He was gonna leave me. He was all I had."
CRISTINA: "Clearly being alone has its benefits."

• Permalink: He said he would leave me if I didn't help him. Things got out ...
• Added: July 24, 2006

"One day? Four razor blades and that's all you can give me? Come on, sugarplum, I thought we were having fun."

CONSTANCE

• Permalink: One day? Four razor blades and that's all you can give me? Come...
• Added: July 24, 2006

IZZIE: "You tell me to cut my losses, that I'm better off without him, and as soon as I turn my back..."
MEREDITH: "C'mon! Alex and I are kind of friends."
IZZIE: "Since when? When did you and Alex become friends?"
MEREDITH: "Don't you think you're overreacting? It's not like I'm going to sleep with him."
IZZIE: "Why not, you've slept with everyone else."

• Permalink: You tell me to cut my losses, that I'm better off without him, ...
• Added: July 24, 2006

GEORGE: "Why Alex? And why again?"
OLIVIA: "People get lonely, George."

• Permalink: Why Alex? And why again? People get lonely, George.
• Added: July 24, 2006

[to himself] "Of course. Crazy nature man! Wants to take a leech home as a pet."

GEORGE

• Permalink: Of course. Crazy nature man! Wants to take a leech home as a p...
• Added: July 24, 2006