Hoxley: That is Nicholas Endicott. And those freezer burns on his neck prove my theory. Someone tried very hard to make it look like he was killed in Estonia.
Officer: What does that mean?
Hoxley: It means I am headed to New York City.

Dr. Capshaw: If he dies...
Martin: Just put it on my tab.

Birdie: So Malcolm, I hear you're profiling murderers for the NYPD. 
Malcolm: Yes, I'm with Major Crimes. 
Birdie: That's quite a demotion from the FBI, isn't it? 
Malcolm: Well, if we all took ten years between career attempts the family trust would run dry.

I do not miss drugs.

Dani

Dani: I want Donahue to be the bad guy.
Malcolm: Yeah, anyone who says "work hard; play hard" has a coke problem. And he clearly has hegemonic masculinity.
Dani: Is that fancy for toxic?
Malcolm: More or less. That's why he works well with Dr. Chabra, who is complicitly masculine. He will tell us the ugly truth.
Dani: How do we get him to talk?
Malcolm: Easy, we just isolate him with our own alpha males.

My sister is like a fungal infection. 

Jessica

Darling, not everyone in your life has a nefarious agenda. Only the men you date.

Birdie [to Jessica]

Ainsley: I keep hearing sirens and helicopters. 
Malcolm: It's New York there are always sirens and helicopters.

Malcolm: So just one murder today?
Dani: What one isn't doing it for ya anymore?
Edrisa: I could keep my ear to the ground if you like.
Malcolm: Actually I could use your help with something. Are you free-
Edrisa: Yes!
JT: He didn't even give a time!
Malcolm: I'll, uh, swing by the lab tonight.
Edrisa: It's a date.

To put it in fun terms, she was botoxed to death.

Edrisa

Dani: You know you're terrible at hiding whatever it is you're trying to hide. 
Malcolm: It's my sister. She's a little lost at the moment.
Dani: And you're trying to keep it all together.
Malcolm: More like failing miserably.
Dani: Well, as someone who was lost once too, my advice is: be there for her, but don't let her drag you down either.
Malcolm: What if she already has?
Dani: How? Bright, whatever it is, you can tell me.
Malcolm: I'm overthinking it.

Malcolm: I have given up everything for you! I don't even know who I am anymore because of what I've done to protect you.
Ainsley: Protect me or control me? You know for someone who has spent the last two decades trying to recover from being gaslit, it's ironic that you resorted to it.
Malcolm: That's not the same. I was trying to save you pain.
Ainsley: That's exactly what Dad would say.

Prodigal Son Quotes

 No one is born broken. Someone breaks us.

Malcolm

Malcolm, Malcolm, listen to me. I want you to remember something, OK? You're my son, and I love you. I will always love you because we're the same. 

Whitly