(Randy breaks it to the quintuplets that their grandma died)
Randy: Everyone who has a grandma, step forward.
(Stan, Cartman, Kenny and quintuplets step forward)
Randy: Not so fast, girls.

We've reached fag factor 5, captain.

Cartman

Grandpa Marsh: That grandma's quite a nice piece of ass.
Randy: Ew, dad! Not in front of Stanley.

(Pulls out an automatic) Hello girls! I'm the easter bunny!

Janet Reno

Stan: I'm tired Grandpa.
Grandpa: No Billy, you're gonna stay here and watch more McGyver, we gotta get all the Frenchy-poo fag nasties outta ya.

Randy: Looks like she had a heart attack in the middle of the night.
Grandpa Marsh: Oh, no wonder she didn't say 'Good night'.
Randy: Ew!

Grandpa: Why the hell do you wanna take these boys to see that fufu French theater crap? You're gonna turn them into poofders!
Sharon: Dad, Stanley needs to see the arts!
Grandpa Marsh: Well he doesn't need to see a bunch of frogs prance around in tights and makeup wrapping their peckers around each other's faces!

Close your eyes and cover your ears Billy! Remember you're a man!

Grandpa Marsh

Oh God that was so funny. Aw man, somebody stop my guts from bursting out of my sides!

Cartman

Kyle: Dude how long does this thing last?
Stan: Two hours.
(the boys groan)

Kyle: Do you guys all think alike?
Quintuplets: (At the same time) No. Of course not. Don't be ridiculous.

Stan: Damn, dude, do you see how much money this place is raking in?
Cartman: Yeah. I could prance around in tights and sing opera too, for that kind of cash.

South Park Season 4 Quotes

Kyle: But you know, I've learned something today. You see, the basis of all reasoning is the mind's awareness of itself. What we think, the external objects we perceive, are all like actors that come on and off stage. But our consciousness, the stage itself, is always present to us.
Cartman: Tits.

Cartman: You guys, you guys! Oh my god, seriously, you guys!
Stan: What the hell's wrong with Cartman?
Kyle: He's fat and stupid.