Sam: Maybe We're dealing with a serial killer?
Dean: You'd love that wouldn't you.

Dean: Bottled toilet water? Why do you keep spraying it?
Sam: I wanted to see if the squeezy thing worked.

I gotta get out of this doily coffin.

Dean

Do you have any idea how much stuff I had to steal, then pawn, to pay for that?

Metatron

Fatherhood changes a man.

Crowley

What he did? Creation? That took work. That took sacrifice. In order to create the world, God had to give up the only thing he had ever known. He had to betray and sacrifice his only kin, The Darkness, his sister.

Metatron

What’s up, doc?

Dean

Dean: Yeah, everything Jesse believes comes true. He thinks the Tooth Fairy looks like Belushi, uh, joy buzzers really shock people, boom that's what happens.
Sam: Yeah, but convince him that joy buzzers don't actually work and they go from killer machines back into crap toys.
Dean: Probably doesn't even know he's doing it. How is he doing it?

Sully: If I show you all we can see, you can’t tell a soul.
Dean: Yeah because chicks dig the whole imaginary friend thing.

Sam: His blood is glittery?
Sully: Even when he’s dead, Sparkle can’t stop shining.

Lucifer: And what was Dad's suggestion?
Sam: To seek out you.
Lucifer: Get out of town, seriously?

Lucifer/Sam: You don't have to be afraid of me, Dean. What do you think I'm going to do.
Dean: I don't know. Maybe deep-fry the planet?
Lucifer/Sam: Why? Why would I want to destroy this stunning thing... beautiful in a trillion different ways. The last perfect handiwork of God? You ever hear the story of how I fell from grace.
Dean: Oh, good god, you're not gonna tell me a bedtime story, are you? My stomach's almost out of bile.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean